Figure: GRIM1 activates GRID1 via GNAQ in dopamine neurons (Human).¶
This figure illustrates the signaling pathway where GRIM1 activates GRID1 via GNAQ in dopaminergic neurons. The pathway begins with GRIM1 in the presynaptic terminal, which along with glutamate (Glu) activates the GRID1 receptor in the postsynaptic density membrane. GRID1 activation leads to activation of GNAQ (G protein), which in turn activates PLCB3 (phospholipase C). PLCB3 produces the second messengers IP3 and DAG. DAG activates PRKCG (protein kinase C), which feeds back to regulate GRID1 receptor activity, completing a regulatory loop in the signaling pathway. The diagram shows the subcellular localization of each component and includes GO terms for molecular functions and cellular components.
Feedback from AI on figure:
{"feedback":"This diagram effectively captures the GRIM1 activation pathway in dopaminergic neurons with scientific precision and artistic clarity. The layout presents a clear flow of information from presynaptic to postsynaptic compartments, with well-defined cellular boundaries and components. The molecular interactions are illustrated with appropriate directional arrows, and each protein is distinctly colored and labeled with both common names and database identifiers. The inclusion of GO terms for molecular functions and cellular components enhances the scientific value, while annotations for interactions provide mechanistic context. The second messengers (IP3 and DAG) are clearly marked with their downstream effects. The legend aids in quick identification of different molecule types, and the overall signal flow indicator helps readers follow the pathway's progression.","necessary_changes":null,"optional_changes":null}