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Figure: Zika virus NS5 inhibition of STAT2 signaling via ZSWIM8 (Human)

id: gomodel:66c7d41500000427

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This diagram illustrates the mechanism by which Zika virus inhibits the host interferon response by targeting STAT2 for degradation. The pathway shows:

  1. Zika virus NS5 protein (Q32ZE1) acts as a protein-macromolecule adaptor in the host cell cytoplasm
  2. NS5 recruits ZSWIM8 (A7E2V4), which functions as a ubiquitin-like ligase-substrate adaptor
  3. CUL3 (Q13618) provides ubiquitin ligase complex scaffold activity
  4. Together, these proteins target STAT2 (P52630) for ubiquitination
  5. Ubiquitinated STAT2 is degraded by the proteasome
  6. This prevents STAT2 from translocating to the nucleus (shown by dashed line with inhibition marker)
  7. In the nucleus, STAT2 would normally function as a DNA-binding transcription factor
  8. The blocked translocation inhibits the type I interferon-mediated signaling pathway

This mechanism represents a viral strategy to suppress the host immune response during infection.

Feedback from AI on figure:

{"feedback":"The diagram effectively illustrates the pathway of Zika virus NS5 protein inhibiting STAT2 signaling via ZSWIM8. The compartments of the host cell are clearly labeled, and the interactions between the proteins are well depicted with appropriate colors and symbols. The increased font sizes improve readability, and the numbered annotations help guide viewers through the process step by step. The comprehensive legend explains all visual elements, making the diagram accessible to both specialists and non-specialists. The overall design follows journal figure standards with clear title, labeled components, and a logical flow of interactions.","necessary_changes":null,"optional_changes":null}