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Figure: CLEC12A acts as an inhibitor of neutrophil activation (Human).

id: gomodel:66c7d41500000715

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This diagram illustrates the CLEC12A-mediated inhibitory pathway of neutrophil activation in humans. The pathway shows:

  1. CLEC12A (Q5QGZ9) - A transmembrane receptor at the neutrophil plasma membrane
  2. SRC (P12931) - A protein tyrosine kinase negatively regulated by CLEC12A
  3. PTPN6/SHP-1 (P29350) and PTPN11/SHP-2 (Q06124) - Protein tyrosine phosphatases activated by SRC
  4. SYK (P43405) - A protein tyrosine kinase inhibited by both phosphatases

The pathway demonstrates how CLEC12A signaling leads to negative regulation of neutrophil activation (GO:1902564) by inhibiting SYK, which is involved in neutrophil activation in immune response (GO:0002283). Inhibitory connections are shown as red dashed lines with T-bars, while activation connections are shown as solid blue lines with arrows.

Feedback from AI on figure:

{"feedback":"The final pathway diagram successfully illustrates the CLEC12A inhibitory pathway in neutrophil activation with excellent clarity and scientific accuracy. The improvements to the drawing include enhanced readability through better spacing and font sizing, clear visual distinction between activation and inhibition pathways, curved connection paths that prevent overlap, increased line thickness and contrast for better visibility, and a well-organized legend. The diagram effectively captures the molecular relationships described in the GO-CAM model, showing how CLEC12A inhibits SRC, which activates the phosphatases PTPN6 and PTPN11, which in turn inhibit SYK kinase activity.","necessary_changes":null,"optional_changes":null}