Figure: heme biosynthetic process (GO:0006783)¶
This diagram illustrates the heme biosynthetic pathway in S. pombe (fission yeast), showing the complete series of enzymatic reactions from glycine to the final products heme A, heme B, and siroheme.
Color coding: - Green circles: Pathway intermediates (glycine, uroporphyrinogen III) - Red circles: Final products (heme A, heme B, heme O, siroheme) - Blue rectangles: Main pathway enzymes (Hem1, Hem2, etc.) - Orange rectangles: Alternate pathway enzymes (Met1/Met8)
Cellular compartmentation is shown with the mitochondrion (light orange), mitochondrial matrix (dotted boundary), and mitochondrial inner membrane (curved orange line).
Key enzymes and their functions: - Hem1 (5-aminolevulinate synthase): Catalyzes the first step from glycine - Hem2-Hem4: Convert intermediates to uroporphyrinogen III - Hem12-Hem14: Further process the molecules toward heme biosynthesis - Hem15 (ferrochelatase): Inserts iron into protoporphyrin IX to form heme B - Fxn1: Iron chaperone that assists Hem15 - Cox10 and Etp1: Convert heme B to heme A via heme O intermediate - Met1/Met8: Enzymes for siroheme biosynthesis pathway
Feedback from AI on figure:
{"feedback":"The drawing effectively captures the complex heme biosynthetic pathway in S. pombe. The diagram clearly illustrates the progression from glycine through various intermediates to the final products (heme A, heme B, and siroheme), with each enzyme appropriately labeled. The cellular compartmentation is well-represented, showing the mitochondrion, matrix, and inner membrane. The color coding is intuitive and the legend helps readers understand the different components. The addition of a brief description below the title provides context for those unfamiliar with the pathway. The text is legible and the overall layout is clean and organized, making it suitable for journal publication.","necessary_changes":null,"optional_changes":null}