Figure: DDX41 activation of the cGAS-STING signaling (Human)¶
The diagram illustrates the DDX41 activation of the cGAS-STING signaling pathway in human cells. BTK (Bruton's tyrosine kinase) in the cytoplasm phosphorylates DDX41 (DEAD-box helicase 41) in the cytosol. Activated DDX41 then stimulates STING1 (stimulator of interferon genes 1) located in the ER-Golgi intermediate compartment membrane. STING1 activation leads to the recruitment and activation of TBK1 (TANK-binding kinase 1) in the cytosol, which ultimately promotes type I interferon production as part of the innate immune response.
Feedback from AI on figure:
{"feedback":"The pathway diagram effectively illustrates the DDX41 activation of the cGAS-STING signaling pathway in human cells. The diagram uses appropriate shapes, colors, and labels to represent each molecule and its function. The cellular compartments (nucleus, cytoplasm, cytosol, and ER-Golgi intermediate compartment) are clearly delineated with distinct visual cues, helping to show the spatial organization of the signaling events. The arrows between components clearly indicate the directionality of the pathway, from BTK phosphorylating DDX41, to DDX41 activating STING1, to STING1 activating TBK1, and finally to the promotion of type I interferon production. The inclusion of a comprehensive legend enhances understanding of the symbols used throughout the diagram.","necessary_changes":null,"optional_changes":null}