Figure: Signaling by PACAP/ADCYAP1 mediated by VIPR1 receptor (Human)¶
The diagram illustrates the PACAP/ADCYAP1 signaling pathway mediated by the VIPR1 receptor in human cells. Key components include:
- ADCYAP1 (P18509): Neuropeptide in extracellular space with hormone activity
- VIPR1 (P32241): Receptor located in the plasma membrane
- GNAS (Q5JWF2): G protein in the cytosol
- ADCY6 (O43306): Adenylate cyclase enzyme producing cAMP
- cAMP (CHEBI:17489): Second messenger
The pathway proceeds in the following sequence: ADCYAP1 binds to VIPR1 receptor → VIPR1 activates GNAS → GNAS activates ADCY6 → ADCY6 produces cAMP. All components operate within the adenylate cyclase-activating G protein-coupled receptor signaling pathway (GO:0007189).
Feedback from AI on figure:
{"feedback":"This figure clearly illustrates the PACAP/ADCYAP1 signaling pathway via the VIPR1 receptor in a style appropriate for a high-impact journal. The diagram effectively shows the sequential activation from extracellular ligand binding through G-protein signaling to second messenger production. The cellular compartmentalization is well-represented, with clear distinction between extracellular space, plasma membrane, and cytosol. The color coding and shapes help distinguish between different types of molecules (neuropeptides, receptors, G proteins, enzymes, and second messengers), and the directional arrows with labeled interactions enhance understanding of the signaling flow. The legend provides comprehensive information about each component, including their identifiers and functional roles within the pathway.","necessary_changes":null,"optional_changes":"For future iterations, consider adding more artistic details to cell components to enhance visual appeal, though the current representation is already clear and scientifically accurate."}