Figure: Signaling by PACAP/ADCYAP1 mediated by VIPR2 receptor (Human)ΒΆ
The diagram illustrates the adenylate cyclase-activating G protein-coupled receptor signaling pathway mediated by PACAP/ADCYAP1 and the VIPR2 receptor in humans (GO:0007189).
Components: 1. ADCYAP1 (P18509) - Pituitary adenylate cyclase-activating polypeptide in the extracellular space with neuropeptide hormone activity (GO:0005184) 2. VIPR2 (P41587) - Vasoactive intestinal peptide receptor 2 in the plasma membrane with PACAP receptor activity (GO:0001634) 3. GNAS (Q5JWF2) - G protein subunit alpha in the cytosol with G protein activity (GO:0003925) 4. ADCY6 (O43306) - Adenylate cyclase 6 with adenylate cyclase activity (GO:0004016) 5. cAMP (CHEBI:17489) - Cyclic adenosine monophosphate, the signaling molecule produced
Pathway flow: - The signaling pathway begins with ADCYAP1 in the extracellular space - ADCYAP1 binds to the VIPR2 receptor embedded in the plasma membrane - Activated VIPR2 stimulates the G protein GNAS in the cytosol - Activated GNAS triggers ADCY6 to produce cAMP - cAMP serves as the second messenger for downstream cellular effects
The diagram represents the exact components and relationships specified in the GO-CAM model (gomodel:66e382fb00000449), with each protein labeled by its UniProt identifier and each activity labeled with its GO term.
Feedback from AI on figure:
{"feedback":"The diagram effectively illustrates the PACAP/ADCYAP1 signaling pathway through the VIPR2 receptor in a clear, visually appealing manner suitable for publication in scientific journals. The use of distinct shapes, colors, and labeled components makes it easy to follow the signaling cascade from extracellular ADCYAP1 through membrane-bound VIPR2 to cytosolic GNAS and ADCY6, ultimately producing cAMP. The numbered steps and directional flow indicators enhance readability, while proper labeling with protein identifiers and GO terms provides scientific precision. The cellular compartments are clearly delineated, and the process flow legend offers a helpful summary of the pathway events.","necessary_changes":null,"optional_changes":null}