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Figure: Signaling by PACAP/ADCYAP1 mediated by PAC1R/ADCYAP1R1 receptor (Human)

id: gomodel:66e382fb00000583

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This diagram illustrates the signaling pathway of PACAP/ADCYAP1 mediated by the PAC1R/ADCYAP1R1 receptor in humans. The pathway is organized into three cellular compartments (extracellular space, plasma membrane, and cytosol) and shows the sequential activation cascade:

  1. The neuropeptide ADCYAP1 (P18509) in the extracellular space binds to and activates the receptor ADCYAP1R1 (P41586) located in the plasma membrane.

  2. Activated ADCYAP1R1 triggers the G protein GNAS (Q5JWF2) in the cytosol.

  3. Activated GNAS stimulates adenylate cyclase ADCY6 (O43306).

  4. ADCY6 catalyzes the production of cyclic AMP (cAMP), the second messenger that propagates the signal intracellularly.

The entire process represents the adenylate cyclase-activating G protein-coupled receptor signaling pathway (GO:0007189). Different shapes and colors are used to distinguish protein types: neuropeptides (red circles), receptors (blue rectangles), G proteins (purple circles), enzymes (green rectangles), and small molecules (yellow circles).

Feedback from AI on figure:

{"feedback":"The diagram effectively illustrates the PACAP/ADCYAP1 signaling pathway through the PAC1R/ADCYAP1R1 receptor in a style suitable for a high-impact journal. The clear organization into cellular compartments (extracellular space, plasma membrane, and cytosol) provides biological context, while the sequential arrangement of proteins shows the signal transduction pathway. The use of distinct shapes and colors for different protein types enhances visual comprehension, and the thickened arrows clearly indicate the direction of signal flow. The comprehensive legend and GO term annotations add scientific rigor. The diagram successfully balances simplicity with scientific accuracy, making it accessible while faithfully representing the GO-CAM model content.","necessary_changes":null,"optional_changes":null}