Figure: BMP3 signaling leading to bone formation inhibition (Human)¶
This figure illustrates the BMP3 signaling pathway that leads to inhibition of bone formation in humans. The pathway consists of four main phases:
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Ligand-Receptor Binding: BMP3 (Bone Morphogenetic Protein 3) in the extracellular space binds to ACVR2B (Activin Receptor Type-2B) on the plasma membrane.
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Signal Transduction: Activated ACVR2B associates with ACVR1B (Activin Receptor Type-1B), forming a functional receptor complex that triggers intracellular signaling.
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Nuclear Translocation: The receptor complex activates SMAD2 and SMAD3 transcription factors, which translocate from the cytoplasm to the nucleus.
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Transcriptional Regulation: In the nucleus, SMAD2 and SMAD3 bind to DNA and function as transcriptional activators, ultimately leading to negative regulation of ossification (bone formation).
Each component is represented with distinct colors: BMP3 (green), ACVR2B (orange), ACVR1B (blue), SMAD2 (red), and SMAD3 (yellow). Colored arrows indicate the direction and type of signaling events, from ligand binding through signal transduction to transcriptional regulation.
Feedback from AI on figure:
{"feedback":"This diagram effectively illustrates the BMP3 signaling pathway leading to bone formation inhibition in humans. The pathway is clearly presented with distinct cellular compartments (extracellular space, plasma membrane, cytoplasm, and nucleus) and a logical flow of signaling events. The addition of numbered phases helps guide the viewer through the sequence of biological processes, from ligand-receptor binding to transcriptional regulation.","necessary_changes":null,"optional_changes":"The diagram accurately represents all components from the GO-CAM model without adding extraneous elements. The consistent font sizing and color scheme create a polished, publication-ready figure suitable for a high-impact journal. The legend comprehensively explains the pathway while remaining concise."}