Figure: BMP3b/GDF10 signaling leading to bone formation inhibition (Human)¶
This figure illustrates the BMP3b/GDF10 signaling pathway leading to inhibition of bone formation in humans. The pathway begins with GDF10 (P55107) in the extracellular space exerting cytokine activity (GO:0005125). GDF10 binds to and activates type I activin receptors ACVR2A (P27037) and ACVR1B (P36896) at the plasma membrane (GO:0005886). Receptor activation leads to signal transduction into the cell, resulting in the activation of SMAD2 (Q15796) and SMAD3 (P84022) transcription factors. These transcription factors translocate to the nucleus (GO:0005634) where they exhibit DNA-binding transcription activator activity (GO:0001228). SMAD2/3 regulate the expression of target genes involved in the negative regulation of ossification (GO:0030279), ultimately inhibiting bone formation. Color coding is used to distinguish different molecular components: pink (extracellular signaling molecules), blue (membrane receptors), green (nuclear transcription factors), orange (gene expression), and red (biological output).
Feedback from AI on figure:
{"feedback":"This diagram effectively illustrates the BMP3b/GDF10 signaling pathway leading to bone formation inhibition. It accurately depicts all the key components from the GO-CAM model while presenting them in a visually appealing manner suitable for publication in high-impact journals. The pathway flow is logical and easy to follow, with clear compartmentalization of cellular components. The color-coding system enhances understanding by distinguishing different types of molecules and cellular locations. All text is now properly positioned and readable without overlapping issues. The inclusion of protein identifiers (UniProt IDs) and GO terms adds scientific precision while maintaining visual clarity.","necessary_changes":null,"optional_changes":null}