Figure: BMP4 signaling pathway (Human)¶
This figure illustrates the human BMP4 signaling pathway (GO:0030509) described in the GO-CAM model. The pathway begins with BMP4 (UniProtKB:P12644) in the extracellular space exhibiting cytokine activity (GO:0005125). BMP4 binds to and activates the type II BMP receptor (BMPR2, UniProtKB:Q13873) on the plasma membrane, which subsequently activates the type I BMP receptor (BMPR1A, UniProtKB:P36894). Activated BMPR1A phosphorylates the R-SMADs: SMAD1 (UniProtKB:Q15797), SMAD5 (UniProtKB:Q99717), and SMAD9 (UniProtKB:O15198). Once phosphorylated, these SMADs translocate to the nucleus where they function as DNA-binding transcription factors (GO:0000981) to regulate target gene expression. All cellular locations and molecular functions depicted are based on the GO terms included in the original GO-CAM model.
Feedback from AI on figure:
{"feedback":"The drawing effectively illustrates the BMP4 signaling pathway with excellent clarity and scientific accuracy. The graphical elements follow a logical flow from extracellular BMP4 through membrane receptor activation to downstream SMAD phosphorylation and nuclear translocation, culminating in transcriptional activity. \n\nThe use of distinct colors for different pathway components (BMP4, receptors, cytoplasmic and nuclear SMADs) with a comprehensive legend enhances comprehension. The subcellular compartments are clearly delineated, and the text labeling is appropriately sized and positioned. The inclusion of phosphorylation marks and the highlighted process annotations (ligand binding, activation, phosphorylation, nuclear translocation) greatly improve the scientific communication of the pathway mechanisms.\n\nThe semi-transparent background boxes behind text annotations ensure readability against the various compartment colors, and the pathway progression is easy to follow through the well-placed directional arrows.","necessary_changes":null,"optional_changes":null}