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Figure: mTORC2 signaling (Human).

id: gomodel:66e382fb00001412

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This figure illustrates the mTORC2 signaling pathway in human cells based on the provided GO-CAM model.

Key components: - MLST8: Functions as a protein-macromolecule adaptor that positively regulates both MTOR and MAPKAP1 - MTOR: Exhibits protein serine/threonine kinase activity at the plasma membrane - MAPKAP1 and RICTOR: Both possess enzyme-substrate adaptor activity and positively regulate MTOR - PDPK1: Activated by MTOR, has protein serine/threonine kinase activity - AKT1: Activated by PDPK1, contributes to PI3K/AKT signaling

The diagram shows how these proteins interact in TORC2 signaling at the plasma membrane and how this pathway connects to PI3K/AKT signaling. The "+" symbols indicate positive regulation between proteins.

All protein interactions and functions shown are derived directly from the GO-CAM model, with no additional gene products added.

Feedback from AI on figure:

{"feedback":"The final diagram clearly illustrates the mTORC2 signaling pathway with excellent visual hierarchy and organization. The enhanced membrane visualization provides better separation between cellular compartments, and the consistent formatting of protein boxes and function labels improves readability. The pathway connections are logically arranged with appropriate directional arrows and regulatory symbols. The inclusion of a legend helps interpret the diagram elements. All required proteins from the GO-CAM model (MLST8, MTOR, MAPKAP1, RICTOR, PDPK1, and AKT1) are properly represented with their correct relationships and functions.","necessary_changes":null,"optional_changes":null}