Figure: EP300 activates the mTORC2 pathway by mediating acetylation of RICTOR (Human).¶
This figure illustrates the pathway by which EP300 activates the mTORC2 signaling pathway leading to AKT1 activation in human cells. EP300 acetylates RICTOR (a component of the mTORC2 complex), enhancing its adapter function. RICTOR then facilitates mTOR kinase activity within the complex located at the plasma membrane. The active mTOR phosphorylates PDK1, which in turn phosphorylates AKT1, promoting PI3K/AKT signaling. The pathway represents key molecular interactions in cell survival and growth signaling.
Feedback from AI on figure:
{"feedback":"The diagram effectively illustrates the EP300 activation of the mTORC2 pathway through RICTOR acetylation in a clear and visually appealing manner. The pathway flow from EP300 to AKT1 is logically presented, with appropriate labeling of protein components and their interactions. The use of distinct colors for different proteins helps differentiate between components, and the inclusion of process indicators (acetylation, phosphorylation) enhances comprehension. The addition of directional arrows on the signaling pathway boxes and a comprehensive legend further improves the clarity of the figure, making it suitable for publication in high-impact journals like Cell or Nature.","necessary_changes":null,"optional_changes":null}