Figure: BMP8A role in spermatogenesis via SMAD1, SMAD5 and SMAD9 (Human)¶
This figure illustrates the BMP8A-mediated signaling pathway in spermatogenesis involving SMAD transcription factors. BMP8A (Q7Z5Y6) in the extracellular space exhibits cytokine activity and binds to receptors BMPR2 (Q13873) and BMPR1A (P36894) on the plasma membrane. This binding initiates a signaling cascade that activates SMAD transcription factors (SMAD1/Q15797, SMAD5/Q99717, and SMAD9/O15198), which translocate to the nucleus where they bind DNA to regulate gene expression associated with spermatocyte development and differentiation.
Feedback from AI on figure:
{"feedback":"The drawing effectively illustrates the pathway of BMP8A's role in spermatogenesis through SMAD signaling. The compartments such as extracellular space, plasma membrane, and nucleus are clearly demarcated. The flow of signaling from BMP8A to BMPR2 and BMPR1A on the plasma membrane, leading to the activation of SMAD1, SMAD5, and SMAD9 transcription factors, is visually clear. The translocation of these SMAD factors to the nucleus is well-represented, indicating their role in gene expression regulation related to spermatogenesis. The use of colors and labels enhances the diagram's comprehensibility, and the addition of a legend improves overall understanding of the symbols used.","necessary_changes":null,"optional_changes":null}