Figure: BMP8B role in adipocyte differentiation inhibition (Human)¶
Legend: - BMP8B: Bone morphogenetic protein 8B, functions as a cytokine (GO:0005125) in the extracellular space - ACVR1B: Activin receptor type-1B (GO:0016361) located on the plasma membrane - SMAD2 & SMAD3: DNA-binding transcription activators (GO:0001228) located in the nucleus - Cellular compartments: Extracellular space (GO:0005615), Plasma membrane (GO:0005886), Nucleus (GO:0005634) - Process: Negative regulation of cell differentiation (GO:0045596) - Solid arrows: Activation relationships (RO:0002409, RO:0002629) - Red dashed arrow: Inhibitory effect on adipocyte differentiation
Feedback from AI on figure:
{"feedback":"The diagram effectively illustrates the BMP8B pathway involved in inhibiting adipocyte differentiation in a clear, publication-ready style suitable for journals like Cell or Nature. The key strengths include:\n\n1. Clear spatial organization showing the different cellular compartments (extracellular space, plasma membrane, nucleus) with appropriate labeling.\n\n2. Logical flow from BMP8B (cytokine) in the extracellular space, to ACVR1B receptor at the plasma membrane, to SMAD2/3 transcription factors in the nucleus.\n\n3. Effective use of different shapes and colors to distinguish between the different molecular components.\n\n4. Clear representation of the inhibitory effect on adipocyte differentiation with a red dashed arrow and \"Inhibits\" label.\n\n5. Simplified labeling that reduces visual clutter while maintaining all essential information, with full details provided in the legend.\n\nThe diagram faithfully represents the GO-CAM model while presenting it in a visually appealing and scientifically accurate manner appropriate for publication.","necessary_changes":null,"optional_changes":null}