Figure: Signaling by Secretin/SCT mediated by SCTR receptor (Human)¶
This figure illustrates the signaling pathway of Secretin (SCT) mediated by the SCTR receptor in humans. The pathway begins with SCT hormone (UniProtKB:P09683) in the extracellular space (GO:0005615) binding to the SCTR receptor (UniProtKB:P47872) embedded in the plasma membrane (GO:0005886). This binding activates the G protein GNAS (UniProtKB:Q5JWF2) in the cytosol (GO:0005829), which in turn activates adenylate cyclase ADCY6 (UniProtKB:O43306), resulting in the production of cyclic AMP (cAMP). The entire process represents the adenylate cyclase-activating G protein-coupled receptor signaling pathway (GO:0007189).
Feedback from AI on figure:
{"feedback":"The diagram effectively illustrates the signaling pathway of Secretin (SCT) through the SCTR receptor in a clear, scientifically accurate format suitable for publication in journals like Cell or Nature. The color-coded components and numbered sequence help readers follow the cascade from hormone binding to cAMP production. Each component is properly labeled with both common names and identifiers, and cellular compartments are clearly delineated. The pathway flows logically from extracellular hormone binding through membrane receptor activation to intracellular signaling steps.","necessary_changes":null,"optional_changes":null}