Figure: cardiolipin metabolic process (GO:0032048) (Spom)¶
This figure illustrates the cardiolipin metabolic process (GO:0032048) in Schizosaccharomyces pombe (S. pombe). The pathway takes place within the mitochondrion, spanning both the mitochondrial matrix and membrane.
Four key enzymes drive this process: 1. Tam41 (SPBC1A4.06c): Located in the mitochondrial matrix, functions as a phosphatidate cytidylyltransferase (GO:0004605) to produce CDP-diacylglycerol. 2. Pgs1 (SPBP18G5.02): Located in the mitochondrial matrix, functions as a CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase (GO:0008444) to convert CDP-diacylglycerol to phosphatidylglycerol phosphate. 3. Gep4 (SPCC645.02): Located in the mitochondrial matrix, functions as a phosphatidylglycerol-phosphatase (GO:0008962) to convert phosphatidylglycerol phosphate to phosphatidylglycerol. 4. Crd1 (SPAC22A12.08c): Located at the mitochondrial membrane, functions as a cardiolipin synthase (GO:0043337) to produce the final product, cardiolipin.
The pathway follows a sequential process where each enzyme catalyzes a specific reaction, with the product of one reaction serving as the substrate for the next. The end product, cardiolipin (CHEBI:62237), is a unique phospholipid found almost exclusively in the inner mitochondrial membrane and is essential for optimal mitochondrial function.
Feedback from AI on figure:
{"feedback":"The illustration effectively captures the cardiolipin metabolic process in S. pombe with clarity and scientific accuracy. The diagram presents a well-organized representation of the mitochondrial structure with clearly delineated outer and inner membranes. Each enzyme (Tam41, Pgs1, Gep4, and Crd1) is distinctly visualized with appropriate placement according to their subcellular localization. The metabolic flow is logically presented with directional arrows, and the inclusion of molecular icons for intermediates enhances understanding without overwhelming detail. The color coding system with a dedicated legend improves readability, and the spacing between elements prevents overlap issues. Text is consistently legible, and the overall aesthetic aligns well with professional journal standards.","necessary_changes":null,"optional_changes":null}