Figure: Fertilization complex allows sperm-egg recognition during fertilization. (Human)¶
This figure illustrates the molecular interactions during human sperm-egg recognition at fertilization. IZUMO1 on the sperm membrane acts as a receptor ligand that binds to IZUMO1R on the egg cell membrane, which functions as a signaling receptor. This key interaction is facilitated by two adaptor proteins on the sperm membrane: SPACA6 and TMEM81. All components are shown at their cellular locations within the plasma membranes of their respective cells. The arrows indicate the direction of interaction, with solid red arrows showing direct binding and dashed blue arrows indicating facilitating interactions. This protein complex is essential for successful fertilization in humans.
Feedback from AI on figure:
{"feedback":"This scientific illustration effectively captures the molecular mechanisms of sperm-egg recognition during human fertilization as described in the GO-CAM model. The drawing clearly depicts the four key proteins (IZUMO1, SPACA6, TMEM81, and IZUMO1R) with their respective molecular functions and cellular locations. The visual hierarchy and color-coding make the interactions easy to follow, while the detailed legend helps interpret the various elements. The addition of explanatory labels on the interactions enhances comprehension, particularly for viewers who may be unfamiliar with the specific terminology. The artistic style is appropriate for publication in high-impact journals like Cell or Nature, with clean lines, professional layout, and balanced use of space.","necessary_changes":null,"optional_changes":null}