Figure: sphingolipid biosynthetic process (GO:0030148)¶
This figure illustrates the sphingolipid biosynthesis pathway in fission yeast (Schizosaccharomyces pombe). The pathway begins in the endoplasmic reticulum (ER) with the condensation of L-serine and palmitoyl-CoA by the serine palmitoyltransferase (SPT) complex (lcb1, lcb2, tsc3), producing 3-ketosphinganine. This is then reduced to dihydrosphingosine by a 3-ketosphinganine reductase (KDHR). Dihydrosphingosine is acylated to form dihydroceramide by the ceramide synthases lag1 and lac1. Dihydroceramide is then desaturated by dsd1 to form ceramide, which is hydroxylated by sur2 and scs7 to produce phytoceramide. Phytoceramide is transported from the ER to the Golgi apparatus by svf1 and svf2, where it is converted to inositol phosphoceramide (IPC) by the IPC synthase complex (aur1, kei1). IPC is then further modified to form mannosylinositol phosphorylceramide (MIPC) by mannosyltransferases (imt1, imt2, imt3). The pathway is regulated by orm1, and the fatty acid elongation machinery (elo1, elo2, phs1, tsc13) provides elongated fatty acids for incorporation into sphingolipids.
Feedback from AI on figure:
{"feedback":"The diagram effectively illustrates the sphingolipid biosynthesis pathway in fission yeast with clear compartmentalization between the ER and Golgi apparatus. The sequential enzymatic reactions are well-represented with appropriate enzyme names and gene identifiers from the source GO-CAM. The flow of metabolites is indicated by directional arrows, with a visually distinct arrow style for transport between compartments. Color coding helps differentiate between metabolites, enzymes, and regulatory elements. Text positioning has been optimized to avoid overlaps, and the addition of a legend clarifies the meaning of the different symbols used in the diagram. The enzyme complexes and their compositions are clearly indicated, and the pathway accurately represents the information from the provided GO-CAM model.","necessary_changes":null,"optional_changes":null}