Figure: Retinoid Metabolic Process 3 (Mouse)¶
This diagram illustrates the retinoid metabolic process in mouse cells based on GO-CAM model 67086be200002592. The pathway shows how retinol (vitamin A) and its derivatives are transported and metabolized across different cellular compartments.
In the extracellular region, Clps (colipase) activates Pnlip (pancreatic lipase), which hydrolyzes retinyl palmitate to release retinol. Lpl (lipoprotein lipase) processes chylomicrons, releasing lipids and retinoids. Retinol is then taken up by cells through Ldlr (low-density lipoprotein receptor) at the plasma membrane.
In the cytosol, Rbp2 (retinol binding protein 2) binds to retinol, functioning as a molecular carrier that facilitates its transport to the endoplasmic reticulum membrane. There, Lrat (lecithin retinol acyltransferase) esterifies retinol to form retinyl esters for storage, while Retsat (retinol saturase) catalyzes the reduction of retinol.
The diagram accurately captures the relationships described in the GO-CAM model, with protein functions, subcellular locations, and molecular transformations represented through distinct shapes and color-coding.
Feedback from AI on figure:
{"feedback":"This refined pathway diagram effectively illustrates the retinoid metabolic process in mouse cells with excellent clarity and scientific accuracy. The cellular compartmentalization is well-represented, showing the movement of retinol and its derivatives through the extracellular space, across the plasma membrane, through the cytosol, and at the endoplasmic reticulum membrane. Each gene product is clearly labeled with both its name and molecular function, enhancing the educational value of the diagram. The color-coding system and legend make it easy to identify different types of molecules and proteins. The arrows and annotations clearly show the directionality and type of interactions (activation, binding, transport, etc.) between components of the pathway.","necessary_changes":null,"optional_changes":null}