Figure: Retinoid Metabolic Process 4 (Mouse)¶
This figure illustrates the Retinoid Metabolic Process in mice, showing the trafficking and metabolism of retinoids across cellular compartments:
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Extracellular: Chylomicrons carrying all-trans-retinyl esters (atREs) are hydrolyzed by Lipoprotein Lipase (Lpl), yielding diglycerides and long-chain fatty acids as byproducts.
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Plasma Membrane: The Low-Density Lipoprotein Receptor (Ldlr) facilitates uptake of retinol into the cell.
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Cytosol: Retinol-Binding Protein 1 (Rbp1) binds all-trans-retinol. Alcohol Dehydrogenase 1 (Adh1) converts retinol to all-trans-retinal. Beta-Carotene Oxygenase 1 (Bco1) produces all-trans-retinal directly. Retinol-Binding Protein 2 (Rbp2) acts as an enzyme-substrate adaptor for retinal. Dehydrogenase/Reductase 3 (Dhrs3) catalyzes the reduction of retinal back to retinol.
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Endoplasmic Reticulum: Lecithin Retinol Acyltransferase (Lrat) catalyzes the esterification of retinol to form all-trans-retinyl esters for storage.
The diagram shows two main metabolic routes: the principal pathway (thick blue arrows) of retinoid processing and storage, and a feedback loop (green dashed arrows) that allows retinal to be converted back to retinol.
Feedback from AI on figure:
{"feedback":"This diagram effectively illustrates the Retinoid Metabolic Process in mice with clear compartmentalization of cellular regions. The use of thicker arrows for main pathways and different colors for gene products and metabolites enhances understanding and visual hierarchy. Each gene product is clearly labeled with both its gene symbol and functional role, which helps readers connect the molecular components to their biological functions. The cellular compartments are distinctly delineated with different background colors, making it easy to track the movement of retinoids throughout the cell. The legend provides a concise explanation of the components and pathways depicted in the figure.","necessary_changes":null,"optional_changes":null}