Figure: GDF8 role in trophoblast invasion (Human)¶
This figure illustrates the GDF8/MSTN signaling pathway in trophoblast cell migration, a critical process in human placentation. The pathway begins with myostatin (MSTN/GDF8) in the extracellular space binding to the activin receptor type-2B (ACVR2B) on the plasma membrane. This interaction activates the TGF-β receptor type I (TGFBR1), triggering phosphorylation of the transcription factors SMAD2 and SMAD3 in the nucleus. These activated SMADs regulate the expression of matrix metalloproteinase-2 (MMP2), which functions as an endopeptidase in the extracellular space to facilitate trophoblast invasion by degrading extracellular matrix components. This molecular cascade demonstrates how GDF8/MSTN contributes to trophoblast migration during placental development.
Feedback from AI on figure:
{"feedback":"The diagram effectively illustrates the GDF8/MSTN signaling pathway in trophoblast cell migration as described in the GO-CAM model. The visual representation is clear and professionally styled for a scientific journal publication. The inclusion of properly labeled cellular compartments (extracellular space, plasma membrane, and nucleus) provides excellent spatial context for the signaling events. The interaction arrows are appropriately labeled to specify the type of molecular actions (binding, activation, phosphorylation, and transcriptional regulation), enhancing the scientific accuracy of the diagram. The comprehensive legend allows readers to easily interpret the colors and symbols used throughout the illustration. The title clearly identifies the biological process being depicted, making this figure suitable for publication in high-impact journals like Cell or Nature.","necessary_changes":null,"optional_changes":null}