Figure: gluconeogenesis I - imported from: Saccharomyces Genome Database

id: gomodel:YeastPathways_GLUCONEO-PWY-1

This figure illustrates the gluconeogenesis I pathway in Saccharomyces cerevisiae, showing the enzymatic conversion of pyruvate to glucose-6-phosphate. The pathway begins in the mitochondrion with pyruvate carboxylation by PYC1/PYC2 to form oxaloacetate, which is then reduced to malate by MAE1. Malate is transported to the cytosol where it is converted back to oxaloacetate by MDH2. The pathway continues with PCK1 converting oxaloacetate to phosphoenolpyruvate (PEP), followed by sequential enzymatic reactions: ENO1/ENO2 (PEP to 2-phosphoglycerate), GPM1 (2-PG to 3-PG), PGK1 (3-PG to 1,3-BPG), and TDH1/2/3 (1,3-BPG to glyceraldehyde-3-phosphate). FBA1 combines G3P and DHAP to form fructose-1,6-bisphosphate, which is then dephosphorylated by FBP1 to fructose-6-phosphate. Finally, PGI1 converts F6P to glucose-6-phosphate. The figure represents the subcellular localization of each step and the directionality of the pathway, with appropriate gene products and metabolites labeled.

Feedback from AI on figure:

{"feedback":"This diagram successfully illustrates the gluconeogenesis pathway in yeast with excellent clarity and organization. The pathway flow is logically presented, showing clear compartmentalization between mitochondrial and cytosolic reactions. All enzymes and metabolites are properly labeled with both common names and identifier codes, making the figure scientifically accurate and informative. The increased font sizes enhance readability, addressing the previous feedback. The inclusion of a brief description at the top provides helpful context, and the legend effectively explains all the elements used in the diagram. The dashed arrow indicating the implicit transport process is appropriately marked, distinguishing it from reactions explicitly defined in the GO-CAM model.","necessary_changes":null,"optional_changes":null}