Figure: folate polyglutamylation - imported from: Saccharomyces Genome Database

id: gomodel:YeastPathways_PWY3O-20

This diagram illustrates the folate polyglutamylation pathway in Saccharomyces cerevisiae (baker's yeast), based on the GO-CAM model. The pathway takes place in the cytosol and involves the conversion of 7,8-dihydropteroate to various folate derivatives.

Key enzymes and reactions include: - FOL3 (dihydrofolate synthase): Converts 7,8-dihydropteroate to dihydrofolate using ATP and L-glutamate - DFR1 (dihydrofolate reductase): Reduces dihydrofolate to tetrahydrofolate using NADPH - MET7 (tetrahydrofolate polyglutamate synthase): Adds glutamate residues to tetrahydrofolate to form THF-Glu(n) - SHM1/SHM2 (glycine hydroxymethyltransferase): Converts tetrahydrofolate and L-serine to 5,10-methylene-tetrahydrofolate and glycine - MIS1/ADE3 (formate-tetrahydrofolate ligase): Converts tetrahydrofolate to 10-formyl-THF using formate and ATP - MET12/MET13 (methylenetetrahydrofolate reductase): Reduces 5,10-methylene-tetrahydrofolate to 5-methyl-THF using NADH

The diagram is color-coded: blue boxes represent enzymes, orange ellipses represent folate metabolites, and green boxes indicate cofactors and substrates.

Feedback from AI on figure:

{"feedback":"The final diagram effectively illustrates the folate polyglutamylation pathway in yeast with improved readability. The color-coding system (blue for enzymes, orange for folate metabolites, green for cofactors/substrates) makes it easy to distinguish between different components. The pathway flow is clear with consistent arrow styles and additional directional indicators, allowing readers to easily follow the reaction sequence. The increased font size enhances readability of chemical names, and the comprehensive legend provides context for interpreting the diagram. Overall, this is a professional-quality scientific illustration suitable for publication in journals like Cell or Nature.","necessary_changes":null,"optional_changes":null}