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Figure: Regulation of sprouting angiogenesis via dll4, egfl6, itgb1a (D. rerio)
Figure: Antifungal innate immune response in the hypodermis via MAPK cascade (C. elegans)
Figure: Antifungal innate immune response in the hypodermis via transforming growth factor beta receptor signaling pathway (C. elegans)
Figure: XBP-1 is a cell-nonautonomous regulator of stress resistance and longevity
Figure: Mouse-Aatf-antiapoptosis
Figure: Protease activity in epithelial morphogenesis via f2rl1.2, spint1a, st14a (D. rerio)
Figure: Migrasome signaling involved in organ morphogenesis via cxcl12a, cxcr4b, tspan4a, tspan7 (D. rerio)
Figure: Inflammatory signaling involved in regulation of hematopoietic stem cell differentiation via notch1a, tnfa, tnfrsf1b, jag1a (D.rerio)
Figure: TBK1 activation via TRAF3 autoubiquitination (Human)
Figure: dAMP catabolic process to allantoin (Mouse)
Figure: IMP catabolic process to allantoin (Mouse)
Figure: Fzd3 function in Cranial neural crest cells
Figure: UMP catabolic process (Mouse)
Figure: dUMP catabolic process (Mouse)
Figure: dTMP catabolic process (Mouse)
Figure: SPModule IFIH1-MAVS
Figure: SP_SIK2-actvity-on-P300
Figure: CMP catabolic process (Mouse)
Figure: Sphingomyelin phosphodiesterase activity involved in viral entry (Human-Sars-Cov-2)
Figure: dCMP catabolic process (Mouse)
Figure: circadian rhythm and hematopoiesis via ezh2, per1b, cry1a etc. (D. rerio)
Figure: Regulation of macrophage differntiation via irf2bp2b, cebpa, spi1b (D. rerio)
Figure: Triacyl lipopetide activation of TLR1-TLR2 complex (Human)
Figure: BMP2-SMAD signaling mouse
Figure: BMP2-MAPK signaling mouse
Figure: SPModule-PGLYRP1/HSP701A
Figure: SPModule-PGRP1-S100A4
Figure: Strap in alternative splicing-mouse
Figure: F13a1 and F13b-mouse-blood clotting
Figure: IL1beta-mediated signaling pathway (Human)
Figure: Wnt-FGF-Notch signaling inregulation of HSC specification via dlc, dld, fgfr4, wnt16 (D. rerio)
Figure: Atf2 mouse
Figure: receptor signaling pathway via JAK-STAT via upd2-dome (D.mel)
Figure: BMP signaling pathway via dpp-tkv/put (D.mel)
Figure: activin receptor signaling pathway via Actbeta-babo/put (D.mel)
Figure: Notch signaling pathway via N-Dl (D.mel)
Figure: TRIM47-activity-on-ILF3
Figure: epidermal growth factor receptor signaling pathway via spi-Egfr (D.mel)
Figure: 'de novo' AMP biosynthetic process (Mouse)
Figure: 'de novo' IMP biosynthetic process (Mouse)
Figure: 'de novo' GMP biosynthetic process (Mouse)
Figure: 'de novo' UMP biosynthetic process (Mouse)
Figure: tumor necrosis factor-mediated signaling pathway via grnd-egr (D.mel)
Figure: 'de novo' XMP biosynthetic process (Mouse)
Figure: GMP salvage 2a, from adenosine (Mouse)
Figure: GMP salvage 2b, from adenosine (Mouse)
Figure: GMP salvage 3, from adenine (Mouse)
Figure: AMP salvage 2b, from adenosine (Mouse)
Figure: NLRP6 inflammasome (Human)
Figure: ERBB2-ERBB4 signaling pathway 3 (Mouse)
Figure: ERBB2-ERBB3 receptor signaling pathway involved in myelination 1 (Mouse)
Figure: Epidermal growth factor receptor signaling pathway 10 (Mouse)
Figure: Activation of ALK and LTK by ALKAL1 and ALKAL2 cytokines (Human)
Figure: IL23 signaling pathway (Human)
Figure: Regulation of gluconeogenesis by SIRT6, FOXO1 and KAT2A/GCN5 (Human)
Figure: CASP7 activates SMPD1 to repair Gasdermin pores in intestinal epithelial cells (Human)
Figure: Poxvirus-OPG044 inhibition of interferon beta induction (Human-Poxvirus)
Figure: CASP7 activates SMPD1 to repair perforin pores in hepatocytes (Human)
Figure: Perforin maturation leading to granzyme-mediated programmed cell death signaling pathway (Mouse)
Figure: Perforin maturation leading to granzyme-mediated programmed cell death signaling pathway (Human)
Figure: Poxvirus-OPG065 inhibition of ZBP1-mediated necroptosis (Human-Poxvirus)
Figure: Poxvirus-OPG025 inhibition of antiviral IFITs (Human-Poxvirus)
Figure: Poxvirus-OPG065 inhibition of ISG15 conjugation (Human-Poxvirus)
Figure: Activation of CASP7 by CASP1 in response to lipopolysaccharide, leading to cleavage and degradation of PARP1 by CASP7 (Human)
Figure: Arginine ADP-riboxanation of CASP4 by by S.flexneri OspC3 that blocks CASP4 activity and pyroptosis (Human)
Figure: Ochratoxin A biosynthesis & catabolism (A. niger)
Figure: Ochratoxin biosynthesis in A. carbonarius
Figure: Ilicicolin H (Neonectria sp. strain DH2)
Figure: Poxvirus-OPG204 inhibition of type I interferon signaling (Human-Poxvirus)
Figure: Poxvirus-OPG043 inhibition of host PKR (Human-Poxvirus)
Figure: Aflaroxin (Aspergillus parasiticus)
Figure: Poxvirus-OPG029 inhibition of host TBK1 adaptor TANK (Human-Poxvirus)
Figure: Poxvirus-OPG029 inhibition of host HDAC4_STAT2 (Human-Poxvirus)
Figure: Poxvirus-OPG062 inhibition of host mTOR/cGAS signaling (Human-Poxvirus)
Figure: Poxvirus-OPG038 inhibition of host CD80/CD86 (Human-Poxvirus)
Figure: Zearalenone biosynthesis (Gibberella zeae)
Figure: Poxvirus-OPG200 inhibition of host IKBKE-mediated NF-Kappa-B (Human-Poxvirus)
Figure: Terrequinone A biosynthesis (Emericella nidulans)
Figure: Poxvirus-OPG193 interferon gamma decoy receptor (Human-Poxvirus)
Figure: Regulation of the JAK-STAT pathway by calmodulin in response to interferon-gamma (Human)
Figure: Regulation of the JAK-STAT pathway by calmodulin in response to interferon-beta (Human)
Figure: USP22 activation of IRF3 via KPNA2 stabilization (Human)
Figure: Insulin receptor signaling pathway 1 (Mouse)
Figure: Arginine ADP-riboxanation of CASP3 by by C.violaceum CopC that blocks CASP3 activity, subsequent apoptosis and pyroptosis (Human)
Figure: Poxvirus-OPG003 inhibition of host NF-kappa-B pathway via NFKB1 (Human-Poxvirus)
Figure: Poxvirus-OPG179 inhibition of host NF-kappa-B via BTRC (Human-Poxvirus)
Figure: Poxvirus-OPG182 inhibition of host NF-kappa-B via IRAK2 (Human-Poxvirus)
Figure: HHV1-US3 inhibition of host RIG-I signaling (Human-Herpesvirus)
Figure: HHV1-US3 inhibition of host NF-kappa-B signaling via RELA (Human-Herpesvirus)
Figure: HHV1-UL37 inhibition of host RIG-I signaling via RIG-I deamidation (Human-Herpesvirus)
Figure: B cell receptor signaling pathway 1 (Mouse)
Figure: Insulin receptor signaling pathway 2 (Mouse)
Figure: Gluconeogenesis 3 (Mouse)
Figure: Insulin receptor signalling pathway 3 (Mouse)
Figure: Inactivation of GSDMD by Protease 3C from Human enterovirus 71 (EV71) (Human)
Figure: Insulin-like growth factor receptor signaling pathway 4 (Mouse)
Figure: HCMV-UL145 inhibition of STAT2 via DDB1/CUL4A (Human-Herpesvirus)
Figure: HIV1-Vpr inhibition of UNG2 via DDB1/CUL4A (Human-Lentivrus)
Figure: HBV-HBX inhibition of Smad5/6 via DDB1/CUL4A (Human-Hepadnavirus)
Figure: Insulin receptor recycling (Mouse)
Figure: PIV5-V inhibition of STAT1 via DDB1/CUL4A (Human-Paramyxovirus)
Figure: Mumps-V inhibition of STAT3 via DDB1/CUL4A (Human-Paramyxovirus)
Figure: Insulin processing 1 (Mouse)
Figure: Gut Microbiota tryptophan metabolism: Regulation of intestinal epithelial cell homesotasis by Indole-AhR (Human-E.coli)
Figure: Protein import into peroxisomes of PTS1-containing proteins by the PEX5 receptor, and recycling of the PEX5 receptor (S.cerevisiae)
Figure: Protein import into peroxisomes of PTS1-containing proteins by the PEX5 receptor, and recycling of the PEX5 receptor (Human)
Figure: TBC1D31/PJA2 complex controls primary ciliogenesis through PKA-directed OFD1 ubiquitylation (Human).
Figure: Regulation of oolemmal binding multimeric complex formation (Mouse)
Figure: Positive regulation of insulin secretion 8 (Mouse)
Figure: HHV1-ICP47 inhibition of MHC class I peptide antigen assembly via TAP1/TAP2 (Human-Herpesvirus)
Figure: Cleavage of NLRP1and GSDMD by SARS-CoV-2 protease Nsp5, leading to inhibition of GSDMD-mediated pyroptosis and concomitant initiation of GSDME-mediated pyroptosis in lung epithelial cells (Human and SARS-CoV-2)
Figure: Activation of GSDME--mediated pyroptosis by NLRP1 in absence of GSDMD (Human)
Figure: positive regulation of transcription from RNA polymerase II promoter by glucose 1 (Mouse)
Figure: TRIM22-NT5C2 regulation of RIGI via ubiquitination (Human)
Figure: Positive regulation of transcription from RNA polymerase II promoter by glucose 3 (Mouse)
Figure: DHX16-mediated viral RNA recognition and activation of RIGI (Human)
Figure: Triglyceride biosynthetic process 1 (Mouse)
Figure: The non-canonical inflammasome mediated by CASP4 upon lipopolysaccharide-binding (Human)
Figure: The non-canonical inflammasome mediated by Casp11 upon lipopolysaccharide-binding (Mouse)
Figure: Irgb10/Gm12250 mediates disruption of the pathogen membrane, liberating ligands that are detected by inflammasomes (Mouse)
Figure: The AIM2 inflammasome (Mouse)
Figure: IRGM governs the core autophagy machinery to conduct antimicrobial defense (Human)
Figure: IpaH9.8 effector protein from S.flexneri ubiquitinate host GBP1, leading to its degradation and inhibition of innate immunity (Human and S.flexneri)
Figure: Zika virus inhibition of TBK1 via CEP63 binding and centrosome disorganization (Human-Zika virus)
Figure: Degradation of NMNAT2 via the PAM (SKP1-FBXO45-MYCBP2) E3 ligase complex (Human)
Figure: Staphylococcal HlgB activation of NF-kappa-B via AMFR and TAB3 (Human-Staphylococcus Aureus)
Figure: TRIM6 activation of antiviral response via unanchored K48-linked polyubiquitin (Human)
Figure: Lysosome biogenesis by TFEB and regulation of nuclear translocation via dephosphorylation by PPP3CB and regulation by IRGM (Human)
Figure: IRGM promotes autophagy-dependent degradation of RIPosomes (NOD1, NOD2 and RIPK2) (Human)
Figure: DCAF13 regulates chromatin reprogramming in the zygote through SUV39H1 and SUV39H2 degradation. (Human)
Figure: FBXO9-mediated degradation of CARM1 leading to epithelial cell survival (Human)
Figure: FBXO7-mediated degradation of SIRT7 leading to cell death in response to hydrogen peroxide (Human)
Figure: Activation of the AIM2 inflammasome in response to DNA damage (Mouse)
Figure: Activation of the AIM2 inflammasome in neural cells shapes neurodevelopment (Mouse)
Figure: Activity of the RQC complex via ubiquitination and degradation of incompletely synthesized nascent proteins (by NEMF and LTN1) following ribosome dissociation (Human)
Figure: Non-canonical activity of the RQC complex via CAT-tailing by NEMF that promotes degradation of incompletely synthesized nascent proteins by the DesCEND pathway (Human)
Figure: Activity of the RQC complex via ubiquitination and degradation of incompletely synthesized nascent proteins (by RQC2 and RKR1/LTN1) following ribosome dissociation (S.cerevisiae)
Figure: tRNA repair and recycling by ANKZF1, ELAC1 and TRNT1 following activity of the RQC complex in response to stalled ribosomes (Human)
Figure: ARKL1 negatively negulates Epstein-Barr virus reactivation by inhibiting JUN-mediated transcription. (Human-Epstein-Barr virus)
Figure: Skeletal muscle acetylcholine-gated channel clustering 1 (Mouse)
Figure: Positive regulation of acetylcholine receptor transcription (Mouse)
Figure: cGAS-STING signaling in the nucleus (Human)
Figure: cGAS-STING signaling in the cytosol (Human)
Figure: Positive regulation of cGAS-STING signaling by TRIM56 (Human)
Figure: Inhibition of cGAS-STING signaling in the nucleus by BANF1 (Human)
Figure: Activation of cGAS-STING signaling following acetylation by KAT5 (Human)
Figure: Activation of canonical mTORC1 following glycosylation of RPTOR by OGT in response to glucose sufficiency (Human)
Figure: Role of 14-3-3epsilon (YWHAE) in RIGI signaling pathway (Human)
Figure: Insulin-mediated activation of the ARF6-RAC1 axis in neurite outgrowth (Human)
Figure: USP49 and SIRT7 inhibition of AKT1 via PHLPP1-mediated dephosphorylation of AKT1 (Human)
Figure: Phosphorylation of MDC1 by CK2 promotes recruitment of NBN and MRN complex to DNA damage sites (Human).
Figure: Phosphorylation of H2AX by ATM or ATR promotes recruitment of NBN and MRN complex to DNA damage sites (Human).
Figure: Ubiquitination of NBN by PELI1 promotes double-strand break repair via homologous recombination (Human).
Figure: Role of USP51 in DNA damage response via DGCR8 deubiquitination (Human)
Figure: Initiation of double-strand break repair via homologous recombination by the MRN complex (MRE11-RAD50-NBN) (Human).
Figure: SKP2 mediates 'Lys-63'-linked ubiquitination of NBN, promoting double-strand break repair via homologous recombination (Human).
Figure: Ubiquitination of NBN by RNF8 promotes double-strand break repair via homologous recombination (Human).
Figure: Lactylation of MRE11 by CREBBP and NBN by KAT5 in response to DNA damage promotes double-strand break repair via homologous recombination (Human).
Figure: RBBP8/CtIP stimulates the endonuclease activity of MRE11 following phosphorylation by ATR and CDK1 (Human).
Figure: Phosphorylation of MRE11 by PLK1 and CK2 inhibits double-strand break repair via homologous recombination (Human).
Figure: Ubiquitination of MRE11 by RNF126 promotes its exonuclease activity (Human).
Figure: DYNLL1 binds to MRE11 to limit DNA end resection (Human).
Figure: MRE11 phosphorylation by ATM dissociates MRE11 from C1QBP inhibitor (Human).
Figure: Regulation of TLR9 by palmitoylation (Human)
Figure: Phosphorylation of NBN regulates DNA repair choice at telomes (Human).
Figure: Cell contact inhibition by Hippo signaling (Human).
Figure: Hippo signaling positive regulation by TAZ cytoplasmic retention (Human).
Figure: Regulation of GSK3B phosphorylation by ZDHHC4-mediated palmitoylation (Human)
Figure: Hippo signaling core components, WWC3 variant (Human).
Figure: Regulation of Hippo signaling by MAP4K4 (Human).
Figure: Negative regulation of Hippo signaling by STRIPAK complex via STRN4:MAP4K4(Human).
Figure: Activation of the GDF15-GFRAL aversive signaling pathway in response to stress (Human).
Figure: Resolution of protein-DNA cross-links by HMCES, BRIP1/FANCJ and SPRTN (Human).
Figure: The MSL complex, composed of MSL1, MSL2, MSL3 and KAT8, mediates acetylation of histone H4 at Lys-16 (H4K16ac) (Human).
Figure: Dosage compensation in male Drosophila by the MSL complex (composed of mle- msl-1, msl-2, msl-3 and mof) (D.melanogaster).
Figure: Inhibition of SMDT1/EMRE and MCU following cleavage by the m-AAA protease complex (composed of AFG3L2 and SPG7) (Human).
Figure: The CRL5(ASB11) complex mediates ubiquitination and degradation of DIRAS2 (Human).
Figure: Role of CD53 in T-cell receptor signaling pathway (Human)
Figure: CARD9 regulation by TRIM62/USP15 (Human)
Figure: DUSP22 inhibition of TCR signaling via UBR2 inhibition (Human)
Figure: Thrombospondin-1/CD36 inhibition of angiogenesis in endothelial cells (Human)
Figure: Mitochondrial calcium uptake by the uniplex complex composed of SMDT1/EMRE, MICU1, MICU2 and MCU (Human).
Figure: Activation of GPR75 by CCL5 in neurons (Human)
Figure: RUFY1 mediates early endosome to Golgi transport. (Human)
Figure: Glycogen biosynthetic process (Dmel)
Figure: Glycogen catabolic process (Dmel)
Figure: MICA-NKG2D mediated NK cell cytotoxicity (Human)
Figure: MICU3 promotes mitochondrial calcium uptake by MCU in the central nervous system (Human).
Figure: MCUB inhibits mitochondrial calcium uptake by the uniplex complex (composed of SMDT1/EMRE, MICU1, MICU2 and MCU) to prevent calcium overload (Human).
Figure: AKT1 affect mitochondrial calcium uptake in response to rapamycin by mediating phosphorylation of MICU1 (Human).
Figure: Ufmylation pathway (Human).
Figure: Ufmylation of RPL26 following translation termination promotes 60S ribosomal subunit recycling (Human).
Figure: UFL1 negatively regulates T-cell activation by mediating ufmylation of PDCD1/PD-1 (Human).
Figure: Control of GABAAR clustering to GABAergic synapses by Gephyrin (Human)
Figure: Positive regulation of glycogen catabolic process 2 (Mouse)
Figure: Positive regulation of cholesterol biosynthesis by PAQR3 by anchoring SREBF1-SCAP complex to the Golgi. (Human)
Figure: Positive regulation of cholesterol biosynthesis by PAQR3 by anchoring SREBF2-SCAP complex to the Golgi. (Human)
Figure: IGF1-mediated signaling via IGF1R receptor (Human)
Figure: IGF2-mediated signaling via IGF1R receptor (Human)
Figure: Signaling by Adrenomedullin mediated by ADM ligand activating CALCRL-RAMP2 receptor complex (Human)
Figure: Signaling by Adrenomedullin mediated by ADM ligand activating CALCRL-RAMP3 receptor complex (Human)
Figure: Signaling by Calcitonin/CGRP mediated by CALCB/CGRP2 ligand activating CALCRL-RAMP1 receptor complex (Human)
Figure: Signaling by Amylin mediated by IAPP ligand activating CALCR-RAMP1 (AMYR1) receptor complex (Human)
Figure: Signaling by Amylin mediated by IAPP ligand activating CALCR-RAMP2 (AMYR2) receptor complex (Human)
Figure: 'De novo' GDP-fucose biosynthetic process 1 (Mouse)
Figure: ITPRIPL1 is a ligand of CD3E that negatively regulates TCR signaling pathway. (Human)
Figure: TMEFF1 restricts herpes simplex virus 1 (HHV-1) infection in the brain by blocking the association between NECTIN1 and the viral envelope glycoprotein D (Human).
Figure: TMEFF1 restricts herpes simplex virus 1 (HHV-1) in the brain by blocking the association between MYH9 and the viral envelope glycoprotein B (Human).
Figure: Thrombopoeitin-mediated signaling pathway (Human)
Figure: PVR-CD226 mediated NK-cell cytotoxicity (Human)
Figure: Activation of the integrated stress response via activation of EIF2AK3/PERK in response to unfolded protein response (Human).
Figure: EIF2AK3/PERK phosphorylates NFE2L2/NRF2 in response to unfolded protein response, preventing the ubiquitination of NFE2L2/NRF2 by KEAP1 (Human).
Figure: NECTIN2-CD226 mediated NK-cell cytotoxicity (Human)
Figure: ATAD3A inhibits the PERK-mediated unfolded protein response in mitochondria by inhibiting EIF2AK3/PERK (Human).
Figure: Activation of the integrated stress response via activation of EIF2AK3/PERK in response to unfolded protein response promotes expression of COX7A2L/SCAF1, increasing formation of respiratory chain supercomplexes (Human).
Figure: Signaling by Calcitonin mediated by CALCA/CT ligand activating CALCR-RAMP2 (AMYR2) receptor complex (Human)
Figure: AKT1 inhibits EIF2AK3/PERK (Human).
Figure: Signaling by Calcitonin mediated by CALCA/CT ligand activating CALCR receptor (Human)
Figure: Signaling by Amylin mediated by IAPP ligand activating CALCR receptor (Human)
Figure: PVR-TIGIT pair inhibits NK cell mediated cytotoxicity (Human)
Figure: GRIM1 activates GRID2 via GNAQ in Purkinje cells (Human).
Figure: ICOSLG-ICOS pair activates T follicular helper cell differentiation (Human)
Figure: GRIM1 activates GRID1 via GNAQ in dopamine neurons (Mouse).
Figure: GRIM1 activates GRID1 via GNAQ in dopamine neurons (Human).
Figure: Signaling by Calcitonin/CGRP mediated by CALCA/CGRP1 ligand activating CALCR-RAMP1 (AMYR1) receptor complex (Human)
Figure: Zika virus NS5 inhibition of STAT2 signaling via ZSWIM8 (Human)
Figure: CLEC12A acts as an inhibitor of neutrophil activation (Human).
Figure: heme biosynthetic process (GO:0006783)
Figure: DDX41 activation of the cGAS-STING signaling (Human)
Figure: DDX39A inhibition of immune related RNA export to the cytoplasm (Human)
Figure: TRAF6 and HUWE1 catalyze branched-linked polyubiquitination that promote NF-kappa-B signaling (Human).
Figure: SP-ANN-SEC14L1
Figure: cGAS-Sting pathway (Drosophila)
Figure: Inhibition of cGAS-STING signaling following dephosphorylation of CGAS by PPP6C (Human)
Figure: SP-ANN_TGM2
Figure: cobalamin transport 2, distribution to tissues (Mouse)
Figure: cobalamin metabolic process 3, methylation of cobalamin (Mouse)
Figure: SP-ANN-TPPP
Figure: Liver apoptosis regulation by CASP6 (Human)
Figure: SP-ANN-RECQL5
Figure: KAT5 regulation of the cytoskeleton by acetylation of proteins (Human)
Figure: KAT5 involvement in nucleotide excision repair (Human)
Figure: KAT5 regulation of lipid droplet disassembly (Human)
Figure: KAT5 chromatin localization (Human)
Figure: Epidermal growth factor receptor signaling pathway 1 (Mouse)
Figure: SP-RNF169
Figure: Fructose catabolic process (Mouse)
Figure: ADP-ribosyltransferase activity of SIRT6 and ADP-ribosylation of PARP1 during DNA repair (Human)
Figure: Galactose catabolic process via UDP-galactose
Figure: Pentose-phosphate shunt 1 (Mouse)
Figure: Pentose-phosphate shunt 2 (Mouse)
Figure: Glycogen biosynthetic process (Mouse)
Figure: IL4-mediated signaling pathway (human)
Figure: IL3-mediated signaling pathway (Human)
Figure: IL5-mediated signaling pathway (Human)
Figure: Glycogen catabolic process 1 (Mouse)
Figure: Role of TONSL and MMS22L (TONSL-MMS22L complex) in promoting homologous recombination-mediated repair of DSBs (Human)
Figure: Glycogen catabolic process 3 (Mouse)
Figure: IL9-mediated signaling pathway (Human)
Figure: Glycosaminoglycan biosynthetic process, linker formation (Mouse)
Figure: Regulation of gluconeogenesis by TOX4 (Mouse)
Figure: IL10-mediated signaling pathway (Human)
Figure: IL11-mediated signaling pathway (Human)
Figure: IL12-mediated signaling pathway (Human)
Figure: 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process (Mouse)
Figure: Heparan sulfate proteoglycan catabolic process (Mouse)
Figure: Regulation of CGAS activity by ZDHHC18 (Human)
Figure: ADP-ribosylation of histones by PARP1 leading to recruitment of CHD1L (Human)
Figure: Chondroitin sulfate catabolic process (Mouse)
Figure: Extraction of PARP1 trapped to chromatin by VCP/p97 following sumoylation by PIAS4 and ubiquitination by RNF4 (Human)
Figure: Regulation of transcription elongation by the P-TEFb complex, NELFE and PARP1 (Human)
Figure: Il17A mediated signaling pathway (Human)
Figure: Activation of PARP1 activity by HPF1 during DNA repair (Human)
Figure: Regulation of Parp1 activity by Cgas, Setd7 and Riox1 (Mouse)
Figure: Regulation of PARP2 activity by PARP1 and recruitment of APLF to DNA damage sites (Human)
Figure: mRNA editing enabled by APOBEC1 (Human)
Figure: HHV1-US11 inhibition of autophagy via TRIM23-TBK1 (Human-Herpesvirus)
Figure: USP20-mediated STING deubiquitination leading to STING stabilisation (Human)
Figure: Positive regulation of insulin secretion 11 (Mouse)
Figure: Tricarboxylic acid cycle 1 (Mouse)
Figure: TRIM27-mediated ubiquitination and degradation of TBK1 (Human)
Figure: Pyruvate catabolic process 1 (Mouse)
Figure: Pyruvate catabolic process 2 (Mouse)
Figure: TRIM27-mediated inhibition of starvation-induced autophagy via ubiquitination of STK38L and ULK1 (Human)
Figure: Xylulose-5-Phosphate biosynthetic process 1 (Mouse)
Figure: Xylulose-5-Phosphate biosynthetic process 2 (Mouse)
Figure: The NLRP3 inflammasome (Human)
Figure: Inhibition of GSDMD-mediated pyroptosis by M.tuberculosis PtpB phosphatase that alters membrane phospholipid composition (Human and M.tuberculosis)
Figure: Activation of the NLRP3 inflammasome by MAPK8/JNK1 and BRCC3 (Human)
Figure: Cellular response to glucagon stimulus (Mouse)
Figure: DCAF12 controls MOV10 during T cell activation. (Human)
Figure: DCAF12 controls MOV10 during spermatogeneis. (Human)
Figure: Isg12a K6-ubiquitination by TRIM21 leading to pyroptosis (Human)
Figure: Negative regulation of glycolytic process through fructose-6-phosphate 2 (Mouse)
Figure: Activation of the CARD8 inflammasome by HIV-1 protease, leading to pyroptosis (Human)
Figure: NOD2 signaling in response to muramyl dipeptide (MDP) leading to NF-kappa-B and MAPK kinase activation (Human)
Figure: NOD1 signaling in response to gamma-D-glutamyl-meso-diaminopimelic acid (iE-DAP) leading to NF-kappa-B and MAP kinase activation (Human)
Figure: NOD2 localization to the plasma membrane following palmitoylation by ZDHHC5 (Human)
Figure: UBL7/TRIM21-mediated ubiquitination of MAVS leading to type I interferon production (Human)
Figure: Activation of Nf-kappa-B via ubiquitination and degradation of the NF-kappa-B inhibitor (Human)
Figure: Coenzyme A biosynthetic process 1 (Mouse)
Figure: Contracted-muscle secreted FN1 activates liver autophagy via hepatic Itga5:Itgb1 integrin receptor signaling. (Mouse)
Figure: Osteocalcin (bglap) hormone produced by osteoblasts binds Gprc6a receptor and regulates testosterone biosynthesis and male fertility (Mouse).
Figure: Smog GPCR signaling, epithelial tube formation (D.mel)
Figure: BMP7 signaling leading to osteoblast differentiation (Human)
Figure: Cell type specific, p53-independent mitotic G2 DNA damage checkpoint signaling mediated by CREB3L1 in astrocytes. (Mouse)
Figure: 14-3-3 sequestering of ZNRF2 E3 ligase leading to ATP1A1 activity at plasma membrane (Human)
Figure: Src-ZNRF1 axis controls TLR3 trafficking (Human)
Figure: Coenzyme A catabolic process 2 (Mouse)
Figure: Canonical mTORC1 signaling (Human)
Figure: Ubiquitination of RagA/RRAGA by RNF152 inhibits the mTORC1 signaling (Human)
Figure: N-terminal myristoylation and palmitoylation of LAMTOR1 mediates its recruitment to lysosome membranes (Human)
Figure: Activation of the mTORC1 signaling by ubiquitination and degradation of GATOR1 subunit DEPDC5 by KLHL22 (Human)
Figure: Activation of the mTORC1 signaling by phosphorylation of GATOR1 subunit DEPDC5 by AKT1 and PIM1 (Human)
Figure: Inhibition of the canonical mTORC1 signaling via ubiquitination and degradation of LAMTOR1 by UBE3A (Human)
Figure: SMAD6 arginine methylation inhibits SMAD1 signaling (Human)
Figure: Inhibition of the canonical mTORC1 signaling via phosphorylation of RPTOR by TBK1 (Human)
Figure: Activation of mTORC1 signaling following phosphorylation of MTOR by TBK1 (Human)
Figure: Major histocompatibility complex class I (MHC I) peptide loading (Human)
Figure: Phosphorylation of AKT1S1/PRAS40 in response to insulin, relieving AKT1S1/PRAS40 inhibitor activity (Human)
Figure: Activation of the canonical mTORC1 signaling in response to insulin via phosphorylation and inhibition of TSC2 (Human)
Figure: USP38 Lys-33 to Lys-48 transition on TBK1 leading to its degratdation (Human)
Figure: HCMV UL138 substains STAT1 activation during viral latency (Human-Cytomegalovirus)
Figure: IL33-signaling pathway (Human)
Figure: Phosphorylation of DEPTOR in response to nutrients leads to its ubiquitination and degradation by the SCF(BTRC) complex (Human).
Figure: Phosphorylation of DEPTOR by MAPK3/ERK1 promotes DEPTOR deubiquitination by USP7 and enhanced protein stability (Human).
Figure: Regulation of T-helper 17 cell lineage commitment by acetylation and deacetylation of STAT3 (Human)
Figure: BRD3 and lncRNA DIGIT form phase-separated condensates to induce endoderm cell differentiation (Human).
Figure: TAX1BP1-mediated degradation of MAVS by E3 ligase ITCH (Human)
Figure: TRIM32-TAX1BP1-dependent selective autophagic degradation of TICAM1 (Human)
Figure: LMNA (Lamin-A/C) maturation (Human).
Figure: KSHV-ORF57 inhibition of host P-body formation (Human-HHV8)
Figure: Regulation of aggrephagy via palmitoylation and depalmitoylation of SQSTM1 by ZDHHC19 and LYPLA1, respectively (Human).
Figure: Regulation of aggrephagy via acetylation and deacetylation of SQSTM1 by KAT5 and HDAC6, respectively (Human).
Figure: SQSTM1 mediates retention of KEAP1 into p62 bodies (Human).
Figure: Regulation of aggrephagy via phosphorylation of SQSTM1 by CK2 (Human).
Figure: Model of MiR-4691-3p inhibition of cGAS-STING signaling in the cytosol (Human)
Figure: Atg7-mediated autophagosome assembly via ATM-CHK2-TRIM32 axis
Figure: Activation of autophagosome assembly by ATM-CHK2-TRIM32-ATG7 axis (Human)
Figure: Regulation of endosomal membrane tethering to cleavage furrow during cytokinesis by the FIP3-Rab11 complex (Human)
Figure: PINK1 role in mitophagy (Human)
Figure: tRNA queuosine promotes further glycosylation by GTDC1 and B3GNTL1, and methylation by TRDMT1 (Human).
Figure: CDK1-mediated deubiquitination of CCNB1 by USP22 leading to G2/M progression (Human)
Figure: BTRC is ubiquitinated and degraded by a Cul5-RING ubiquitin ligase complex (Human).
Figure: ubiquinone metabolic process (GO:0006743 )
Figure: isoprenoid biosynthetic process (GO:0008299)
Figure: GSDMD palmitoylation by ZDHHC5 and ZDHHC9 promotes pyroptosis (Human).
Figure: Gsdmd palmitoylation by Zdhhc5 and Zdhhc9 promotes pyroptosis (Mouse)
Figure: O-GlcNAcylation of GSDMD by OGT inhibits the non-canonical inflammasome assembly (Human)
Figure: Activation of the non-canonical inflammasome mediated by Casp11 upon lipopolysaccharide-binding can lead to blood-brain barrier breakdown (Mouse)
Figure: Activation of the non-canonical inflammasome mediated by CASP4 upon lipopolysaccharide-binding can lead to blood-brain barrier breakdown (Human)
Figure: TRAIL/TRAILR1 interaction leading to apoptosis
Figure: Regulation of TNF-alpha-mediated signaling pathway by TMC8 (Human)
Figure: oxidative phosphorylation (GO:0006119)
Figure: Pyroptotic cell death mediated by GSDMD and NINJ1 (Human).
Figure: TRAIL/TRAILR2 interaction leading to apoptosis
Figure: FASL-FAS interaction leading to apoptosis (human)
Figure: CD40-CD40L proximal activation of TRAF2 and TRAF5 (Human)
Figure: purine nucleobase metabolic process (GO:0006144)
Figure: phosphatidylinositol phosphate/phosphatidylinositol/ biosynthetic process (GO:0006661)(GO:0043647)
Figure: canonical glycolysis (GO:0061621)
Figure: TGFB1-mediated signaling pathway (Human)
Figure: TGFB2-mediated signaling pathway (Human)
Figure: TGFB3-mediated signaling pathway (Human)
Figure: PF4-Thrombomodulin pair activating Protein C activation (Human)
Figure: CD93/Multimerin-2/β1 integrin complex function in angiogenesis (Human)
Figure: Thrombin-Thrombomodulin pair activating Protein C activation (Human)
Figure: CD70-CD27 ligand receptor in T cell activation
Figure: HTR2C-mediated serotonin signaling via G-alpha-q/11 (phospholipase c-activating, IP3, DAG) (Human).
Figure: ROR1 activation by IGFB5 leading to cell proliferation (Human)
Figure: CD48-CD244 ligand receptor binding in NK cell activation
Figure: Androgen biosynthesis 1 (Mouse)
Figure: Androgen biosynthetic process 2 (Mouse)
Figure: GDF8 role in trophoblast invasion (Human)
Figure: canonical Wnt signaling pathway via wg-fz2 (D.mel)
Figure: SIRT6 inactivation by lncPRESS1 RNA (Human)
Figure: Microtubule polyglutamylation regulation (Human)
Figure: Regulation of cholesterol biosynthesis by SREBP (SREBF1 and SREBF2) and retention by the SREBP-SCAP complex (Human)
Figure: IL2 signaling pathway (Human)
Figure: Chondroitin sulfate biosynthetic process 1, chondroitin 6-sulfate proteoglycans (Mouse)
Figure: Granzyme-mediated (GZMA) activation of pyroptosis (GSDMB isoform 4) (Human)
Figure: Cytotoxic T cell pyroptosis mediated by GSDMB isoform 1 in response to infection by Gram-negative bacteria and its inhibition by S.flexneri IpaH7.8 (Human and S.flexneri)
Figure: Regulation by IL22 and Reg3g of allergic airway inflammation. (Mouse)
Figure: Regulation by IL22 and REG3A of allergic airway inflammation. (Human)
Figure: Negative regulation of inflammatory response to wounding by REG3A. (Human)
Figure: USP44-mediated FOXP3 deubiquitination leading to regulatory T-cell differentiation (Human)
Figure: USP44-mediated deubiquitination of CDC20 controlling anaphase initiation (Human)
Figure: Ascorbic acid biosynthetic process 1 (Mouse)
Figure: Ascorbic acid biosynthetic process 2 (Mouse)
Figure: MYD88-dependent TLR4 signaling pathway leading to autophagy activation (Human)
Figure: MYD88-independent TLR4 signaling pathway leading to interferon production (Human)
Figure: Positive regulation of epidermal growth factor receptor signaling pathway 1 (Mouse)
Figure: Thiamine diphosphate biosynthetic process 1 (Mouse)
Figure: Thiamine diphosphate biosynthetic process 2 (Mouse)
Figure: Vitamin B2 (riboflavin) metabolic process to FAD (Mouse)
Figure: Inosine catabolic process (Mouse)
Figure: NLRP3 inflammasome in pyroptosis via nlrp3, caspa, caspb etc. (D. rerio)
Figure: Guanine catabolic process (Mouse)
Figure: Deoxyadenosine catabolic process (Mouse)
Figure: Deoxyguanosine catabolic process (Mouse)
Figure: Deoxyinosine catabolic process (Mouse)
Figure: IMP salvage (Mouse)
Figure: cobalamin metabolic process 1, adenosylation of cobalamin (Mouse)
Figure: DNA damage sensor activity of SIRT6 and its regulation by SIRT1 (Human)
Figure: Mono-ADP-ribosylation of ribosome subunits by PARP16 (Human)
Figure: Histone poly-ADP-ribosylation of histone H2B at Glu-35 by Parp1 that prevents phosphorylation at of histone H2B at Ser-36 by Prkaa1 (Mouse)
Figure: Regulation of ACLY by acetylation by PCAF/KAT2B and ubiquitination (by UBR4) (Human)
Figure: Lysosome biogenesis by TFEB and regulation of cytoplasmic retention via phosphorylation by MTOR or alkylation (Human)
Figure: PTEN in excitatory hippocampal synapse long-term depression (Human)
Figure: Casp7 activates Smpd1 to repair Gasdermin pores in intestinal epithelial cells (Mouse)
Figure: Casp7 activates Smpd1 to repair perforin pores in hepatocytes (Mouse)
Figure: Cobalamin transport, into enterocytes (Mouse)
Figure: Dermatan sulfate catabolic process (Mouse)
Figure: ARRDC4-mediated activation of MDA5 through K63-ubiquitination by TRIM65 (Human)
Figure: Positive regulation of glycolytic process 1 (Mouse)
Figure: STING1 acts as a proton channel and promotes autophagosome assembly (Human)
Figure: Regulation of CGAS activity via palmitoylation and depalmitoylation by ZDHHC9 and LYPLAL1, respectively (Human).
Figure: STING1 trafficking from the endoplasmic reticulum and the ERGIC following phosphorylation by MAP3K7/TAK1 and interaction with STEEP1 (Human)
Figure: TRIM55 and TRIM21-mediated inhibition of NFKB2 (Human)
Figure: USP9X-TRIM32 modulation of IQCB1 during G2-M (Human)
Figure: cardiolipin metabolic process (GO:0032048) (Spom)
Figure: Fertilization complex allows sperm-egg recognition during fertilization. (Human)
Figure: sphingolipid biosynthetic process (GO:0030148)
Figure: Retinoid Metabolic Process 3 (Mouse)
Figure: Retinoid Metabolic Process 4 (Mouse)
Figure: TRAF7 modulation of NF-kappa-B via IKBKG and NEMO K-29 ubquitination (Human)
Figure: Mpeg1/perforin-2 forms a pore for to deliver antigens for cross-presentation (Mouse)
Figure: MPEG1/perforin-2 forms a pore for to deliver antigens for cross-presentation (Human)
Figure: Glyceraldehyde-3-phosphate biosynthetic process 1 (Mouse)
Figure: SUCNR1 in adipocytes controls energy homeostasis by modulating circadian clock and LEP expression. (Human)
Figure: tricarboxylic acid cycle (GO:0006099)
Figure: GPI anchor biosynthetic process (GO:0006506)
Figure: pericentric heterochromatin formation (GO:0031508)
Figure: subtelomeric heterochromatin formation (GO:0031509)
Figure: nitrogen cycle metabolic process (GO:0071941)
Figure: Angiopoietin-1-Thrombomodulin pair inhibiting Protein C activation (Human)
Figure: Glucuronate catabolic process to xylulose 5-phosphate (Mouse)
Figure: Regulation of the mTORC1 signaling via ubiquitination and deubiquitnation of SESN2 by RNF167 and STAMBPL1 (Human)
Figure: Regulation of the mTORC1 signaling via ubiquitination and degradation of CASTOR1 by RNF167 (Human)
Figure: Renin-angiotensin pathway (Human)
Figure: IL7-mediated signaling pathway (Human)
Figure: TSLP-mediated signaling pathway (Human)
Figure: hyaluronan biosynthetic process (Mouse)
Figure: Hyaluronan catabolic process (Mouse)
Figure: Regulation of ion transport in the distal nephron by WNK4 (Human)
Figure: Ubiquitination of WNK4 in the distal nephron by KLHL3 and its regulation by phosphorylation and dephosphorylation (Human)
Figure: iron-sulfur cluster assembly (GO:0016226) and iron-sulfur cluster export from the mitochondrion (GO:0140466)
Figure: arginine biosynthesis
Figure: Protein O-linked glycosylation 1 (Mouse)
Figure: AARS1 mediates lactylation of YAP1 and TEAD1, promoting activation of Hippo signaling (Human).
Figure: SIRT1 mediates delactylation of YAP1 and TEAD1, promoting inactivation of Hippo signaling (Human).
Figure: tryptophan biosynthetic process (GO:0000162)
Figure: L-histidine biosynthetic process (GO:0000105)
Figure: Extrinsic apoptotic signaling pathway via death domain receptors 1(Mouse)
Figure: Inhibition of ALKBH5 RNA demethylase activity by sumoylation in response to reactive oxygen species (Human)
Figure: RBM33 binds N6-methyladenosine (m6A)-containing mRNAs and promotes their demethylation by ALKBH5 RNA demethylase (Human)
Figure: GBP1 GTPase promotes assembly of the non-canonical inflammasome via association with lipopolysaccharide (Human).
Figure: Activation of the canonical mTORC1 signaling by PRMT1 in response to S-adenosyl-L-methionine influx (Human)
Figure: USP25-mediated stabilization of KEAP1 leading to NRF2 degradation (Human)
Figure: Intestinal smooth muscle cell differentiation via foxo1a, mir145, tgfr1b, ltbp3, zeb1a (D. rerio)
Figure: ERBB2-EGFR signaling pathway 1 (Mouse)
Figure: Silencing of fetal hemoglobin by ZNF410 (Human)
Figure: Epidermal growth factor receptor signaling pathway 2 (Mouse)
Figure: Epidermal growth factor receptor signaling pathway 3 (Mouse)
Figure: ERBB2-ERBB4 signaling pathway 2 (Mouse)
Figure: Fatty acid transport by CD36 via LYN-mediated endocytosis (Human)
Figure: Regulation of the canonical mTORC1 signaling via ubiquitination and deubiquitination of RHEB by RNF152 and USP4, respectively (Human)
Figure: Regulation of the canonical mTORC1 signaling via deubiquitination of RHEB by ATXN3 in response to starvation (Human)
Figure: Biotin Metabolic Process 1 (Mouse)
Figure: Inhibition of the canonical mTORC1 signaling via phosphorylation of RPTOR by AMPK in response to glucose starvation (Human)
Figure: Molybdopterin Cofactor Biosynthetic Process 1 (Mouse)
Figure: Tumor necrosis factor-mediated signaling pathway 2 (Mouse)
Figure: Heme A biosynthetic process (Mouse)
Figure: Heme O biosynthetic process (Mouse)
Figure: Heme B biosynthetic process (Mouse)
Figure: CD69-OxydizedLDL pair leading to PD-1 expression in T-cells (Human)
Figure: LGALS1-CD69 pair involved in negative regulation of T-helper 17 cell lineage (Human)
Figure: 18S rRNA degradation in response to ribosome collision by HEL2, leading to ubiquitination of RPS3/uS3 by MAG2, RSP5 and HEL2 and rRNA degradation (S.cerevisiae).
Figure: TREM2 activated by APOE. (Human)
Figure: Activation of the GCN2-mediated signaling by GCN1 in response to ribosome collisions and inhibition of GCN2 by HEL2 (S.cerevisiae)
Figure: Activation of the NLRP1 inflammasome by isoform ZAKalpha of MAP3K20 in response to UV-B irradiation and ribotoxic stress (Human)
Figure: Activation of the No-Go decay (NGD) pathway in response to ribosome collision by HEL2, leading to ubiquitination of RPS7/eS7, recruitment of CUE2 and mRNA degradation (S.cerevisiae).
Figure: Activation of the ribosome quality control by HEL2 in response to ribosome collisions, leading to ubiquitination of RPS20/us10 and ribosome dissociation by the RQT complex, composed of CUE3, RQT4 and SLH1 (S.cerevisiae)
Figure: adenylate cyclase-activating G protein-coupled receptor signaling pathway (GO:0007189)
Figure: CD21/FCRL5 receptor role in B-cell activation (Human)
Figure: CD72 and BCR co-stimulation by sn/RNP self antigen (Human)
Figure: Extraction of mRNA from stalled ribosomes by the SKI complex, leading to recruitment of the PELO-HBS1L complex that binds to stalled ribosomes, followed by ribosome dissociation by ABCE1 (Human)
Figure: Feedback regulation of erythropoietin-mediated signaling via ubiquitination and degradation of EPOR by the ECS(SOCS2) complex (Human).
Figure: Feedback regulation of growth hormone receptor signaling pathway via ubiquitination and degradation of GHR by the ECS(SOCS2) complex (Human).
Figure: FMDV-3A inhibition of host IRF3 via DDX56 (Human-Aphthovirus)
Figure: GDP-mannose biosynthetic process from glucose (Mouse)
Figure: HIV-1 Vif protein hijacks a cullin-5-RING E3 ubiquitin-protein ligase to mediate ubiquitination and degradation of APOBEC3G (Human).
Figure: HTATSF1 and TOPBP1 promote RPA-RAD51 exchange in double-strand break repair via homologous recombination (Human).
Figure: IFNA1-CR2 role in B-cell ISGs induction (Human)
Figure: Inhibition of reelin signaling via ubiquitination and degradation of DAB1 by the ECS(SOCS7) complex in the cortical plate of the developing cerebral cortex (Human).
Figure: Insulin-like growth factor receptor signaling pathway 2 (Mouse)
Figure: Insulin-like growth factor receptor signaling pathway 3 (Mouse)
Figure: Phosphorylation-mediated interactions with TOPBP1 couples TP53BP1 and 9-1-1 in DNA damage checkpoint (Human).
Figure: Recruitment of TOPBP1 to DNA damage sites by MDC1 during mitosis (Human)
Figure: Regulation of energy homeostasis by OTUD3 (Human)
Figure: RNA capping (GO:0036260)
Figure: SECTM1-CD7 interaction leading to cytokine production upon T-cell activation (Human)
Figure: septation initiation signaling (GO:0031028)
Figure: silent mating-type cassette heterochromatin assembly (GO:0030466)
Figure: The CRL5(ASB9) complex mediates ubiquitination and degradation of CKB (Human).
Figure: The CRL5(ASB11) complex mediates ubiquitination and degradation of BIK in response to endoplasmic reticulum stress (Human).
Figure: The ECS(SPSB3) complex mediates ubiquitination and degradation of CGAS in the nucleus during mitotic interphase (Human).
Figure: The ECS(SPSB3) complex mediates ubiquitination and degradation of GSK3B-phosphorylated SNAI1 (Human).
Figure: The erythropoietin-mediated signaling pathway (Human).
Figure: The growth hormone receptor signaling pathway (Human).
Figure: The reelin signaling pathway (Human).
Figure: The SCF(FBXO11) complex mediates ubiquitination and degradation of GSK3B-phosphorylated SNAI1 (Human).
Figure: TRIM69 activation of STK3 by ubiquitination leading to centrosome separation (Human)
Figure: UBR4 and UBR5 catalyze branched-linked polyubiquitination of substrates, leading to proteasome-mediated degradation of substrates (Human).
Figure: UBR5 ubiquitinates ligand-bound PGR when PGR is not associated with Nuclear receptor coactivators (NCOAs) (Human).
Figure: UBR5 ubiquitinates ligand-bound RARA and RXRA when RARA and RXRA are not associated with Nuclear receptor coactivators (NCOAs) (Human).
Figure: UBR5 ubiquitinates ligand-bound VDR when VDR is not associated with Nuclear receptor coactivators (NCOAs) (Human).
Figure: dTMP biosynthetic process1A (Mouse)
Figure: UDP biosynthetic process (Mouse)
Figure: Tetrahydrofolate interconversion 1a (Mouse)
Figure: Signaling by Vasoactive Intestinal Peptide/VIP mediated by VIPR1 receptor (Human)
Figure: Signaling by Vasoactive Intestinal Peptide/VIP mediated by VIPR2 receptor (Human)
Figure: Signaling by PACAP/ADCYAP1 mediated by VIPR1 receptor (Human)
Figure: Signaling by PACAP/ADCYAP1 mediated by VIPR2 receptor (Human)
Figure: Signaling by PACAP/ADCYAP1 mediated by PAC1R/ADCYAP1R1 receptor (Human)
Figure: BMP3 signaling leading to bone formation inhibition (Human)
Figure: BMP3b/GDF10 signaling leading to bone formation inhibition (Human)
Figure: BMP4 signaling pathway (Human)
Figure: mTORC2 signaling (Human).
Figure: EP300 activates the mTORC2 pathway by mediating acetylation of RICTOR (Human).
Figure: GSK3B inhibits the mTORC2 pathway by mediating phosphorylation of RICTOR in response to endoplasmic reticulum stress (Human).
Figure: BMP8A role in spermatogenesis via SMAD1, SMAD5 and SMAD9 (Human)
Figure: BMP8B role in adipocyte differentiation inhibition (Human)
Figure: Signaling by Secretin/SCT mediated by SCTR receptor (Human)
Figure: TBK1 activates the mTORC2 signaling by mediating phosphorylation of MTOR (Human).
Figure: mTORC1 and mTORC2 inhibit insulin receptor signaling by promoting ubiquitination and degradation of IRS1 by the CUL7(FBXW8) complex (Human).
Figure: ZDHHC1 promotes activation of the NLRP3 inflammasome by mediating palmitoylation of NLRP3, leading to NLRP3 phosphorylation by LATS1 and activation of NLRP3 by NEK7 (Human)
Figure: Protein lipoylation 1 (Mouse)
Figure: Cacna1a (MGI:MGI:109482)
Figure: gluconeogenesis I - imported from: Saccharomyces Genome Database
Figure: superpathway of threonine and methionine biosynthesis - imported from: Saccharomyces Genome Database
Figure: folate polyglutamylation - imported from: Saccharomyces Genome Database
Figure: 2-oxoglutarate decarboxylation to succinyl-CoA - imported from: Saccharomyces Genome Database
Figure: TCA cycle, aerobic respiration - imported from: Saccharomyces Genome Database
Guidelines
Guidelines
DNA binding transcription factor activity annotation guidelines
E3 ubiquitin ligases
GO CAM annotation guidelines README
GO CAM modelling guidelines TO DO
How to annotate complexes in GO-CAM
How to annotate molecular adaptors
Sequestering activity
Guidelines for annotating molecular adaptor activity
Molecular carrier activity
Guidelines for annotating molecular sequestering activity
Signaling receptor activity annotation guidelines
Transcription coregulator activity
Guidelines for annotating transporter activity
Guidelines for annotating regulation and regulatory processes in GO-CAM
Reviews
Reviews
5ae3b0f600000435 Regulation of sprouting angiogenesis via dll4 egfl6 itgb1a D rerio
5b91dbd100002057 Antifungal innate immune response in the hypodermis via MAPK cascade C elegans
5b91dbd100002241 Antifungal innate immune response in the hypodermis via transforming growth factor beta receptor signaling pathway C elegans
5b528b1100000489 XBP 1 is a cell nonautonomous regulator of stress resistance and longevity
5ce58dde00001215 Mouse Aatf antiapoptosis
5df932e000000330 Protease activity in epithelial morphogenesis via f2rl1 2 spint1a st14a D rerio
5ee8120100000524 SP N4BP3on MAVS
5ee8120100001898 Migrasome signaling involved in organ morphogenesis via cxcl12a cxcr4b tspan4a tspan7 D rerio
5ee8120100002841 Inflammatory signaling involved in regulation of hematopoietic stem cell differentiation via notch1a tnfa tnfrsf1b jag1a D rerio
5f46c3b700001031 MYD88 dependent TLR4 signaling pathway leading to NF kappa B activation Human
5f46c3b700001407 TBK1 activation via TRAF3 autoubiquitination Human
5f46c3b700001570 SPModule TBK1 IRF3
5f46c3b700002102 SPModule TIRAP MYDDOSOME
5f46c3b700002685 IL6 sIL6R Trans signaling pathway Human
5f46c3b700003802 dGMP catabolic process to allantoin Mouse
5f46c3b700003884 AMP catabolic process to allantoin Mouse
5fa76ad400000018 AMP catabolic process 2 Mouse
5fa76ad400000110 GMP catabolic process to allantoin Mouse
5fa76ad400000265 dAMP catabolic process to allantoin Mouse
5fa76ad400000374 IMP catabolic process to allantoin Mouse
5fadbcf000000317 Fzd3 function in Cranial neural crest cells
5fadbcf000000480 UMP catabolic process Mouse
5fadbcf000000868 dUMP catabolic process Mouse
5fadbcf000000942 dTMP catabolic process Mouse
5fadbcf000001101 SPModule IFIH1 MAVS
5fadbcf000001646 SP SIK2 actvity on P300
5fadbcf000001962 T helper 17 cell lineage commitment by IL6 cluster Human
5fadbcf000002042 CMP catabolic process Mouse
5fadbcf000002129 Sphingomyelin phosphodiesterase activity involved in viral entry Human Sars Cov 2
5fadbcf000002236 dCMP catabolic process Mouse
5fb9cc0600000156 circadian rhythm and hematopoiesis via ezh2 per1b cry1a etc D rerio
5fb9cc0600000627 Regulation of macrophage differntiation via irf2bp2b cebpa spi1b D rerio
5fb9cc0600000727 Triacyl lipopetide activation of TLR1 TLR2 complex Human
5fce9b7300000367 BMP2 SMAD signaling mouse
5fce9b7300000434 BMP2 MAPK signaling mouse
5fce9b7300001590 SPModule PGLYRP1 HSP701A
5fce9b7300001616 SPModule PGRP1 S100A4
5fce9b7300001742 Strap in alternative splicing mouse
5fce9b7300002336 SPModule TREM1 DAP12
5fce9b7300002436 TREM2 activated by APP
57c82fad00000695 F13a1 and F13b mouse blood clotting
59cc772c00000000 IL1beta mediated signaling pathway Human
59dc728000000555 Wnt FGF Notch signaling inregulation of HSC specification via dlc dld fgfr4 wnt16 D rerio
60ad85f700000058 Atf2 mouse
60ad85f700000110 receptor signaling pathway via JAK STAT via upd2 dome D mel
60ad85f700000189 BMP signaling pathway via dpp tkv put D mel
60ad85f700000259 activin receptor signaling pathway via Actbeta babo put D mel
60ad85f700000309 Notch signaling pathway via N Dl D mel
60ad85f700000612 TRIM47 activity on ILF3
60ad85f700001873 epidermal growth factor receptor signaling pathway via spi Egfr D mel
60ad85f700002694 de novo AMP biosynthetic process Mouse
60ad85f700002947 de novo IMP biosynthetic process Mouse
60ad85f700003015 de novo GMP biosynthetic process Mouse
60ad85f700003288 de novo UMP biosynthetic process Mouse
60d5209a00000233 tumor necrosis factor mediated signaling pathway via grnd egr D mel
60d5209a00000521 torso signaling pathway D mel
60d5209a00001406 de novo XMP biosynthetic process Mouse
60ff660000000882 GMP salvage 2a from adenosine Mouse
60ff660000000897 GMP salvage 2b from adenosine Mouse
60ff660000000917 GMP salvage 3 from adenine Mouse
60ff660000001341 AMP salvage 2b from adenosine Mouse
61b2b68300000000 NLRP6 inflammasome Human
61b2b68300000203 ERBB2 ERBB4 signaling pathway 3 Mouse
61b2b68300000617 ERBB2 ERBB3 receptor signaling pathway involved in myelination 1 Mouse
61e0e55600000239 Epidermal growth factor receptor signaling pathway 10 Mouse
61e0e55600000407 SP GADD34 PPP1CA
61e0e55600000430 Epidermal growth factor receptor signaling pathway 11 Mouse
61e0e55600000624 Cyclin D ubiquitination and degradation by AMBRA1 Human
61e0e55600001225 Gluconeogenesis 1 Mouse
61e0e55600001295 NLRP1 inflammasome leading to pyroptosis Human
61e0e55600001659 Granzyme mediated GZMB activation of pyroptosis GSDME Human
61e0e55600002253 Activation of ALK and LTK by ALKAL1 and ALKAL2 cytokines Human
61f34dd300000863 PKM2 acetylation by EP300 and deacetylation by SIRT6 leading to conversion into a protein kinase Human
61f34dd300000981 Regulation of gluconeogenesis by SIRT6 FOXO1 and KAT2A GCN5 Human
61f34dd300001044 Yeast ergosterol
62b4ffe300000010 CASP7 activates SMPD1 to repair Gasdermin pores in intestinal epithelial cells Human
62b4ffe300000067 Poxvirus OPG044 inhibition of interferon beta induction Human Poxvirus
62b4ffe300000081 CASP7 activates SMPD1 to repair perforin pores in hepatocytes Human
62b4ffe300000240 Perforin maturation leading to granzyme mediated programmed cell death signaling pathway Mouse
62b4ffe300000241 Poxvirus CRMB inhibition of TNF signaling pathway Human Poxvirus
62b4ffe300000335 Perforin maturation leading to granzyme mediated programmed cell death signaling pathway Human
62b4ffe300000504 Poxvirus OPG065 inhibition of ZBP1 mediated necroptosis Human Poxvirus
62b4ffe300000717 Poxvirus OPG025 inhibition of antiviral IFITs Human Poxvirus
62b4ffe300000784 Involvement of CASP7 in apoptosis its activation by initiator caspases CASP8 CASP9 and CASP10 and regulation by XIAP and PAK2 Human
62b4ffe300000906 Poxvirus OPG065 inhibition of ISG15 conjugation Human Poxvirus
62b4ffe300001832 Activation of CASP7 by CASP1 in response to lipopolysaccharide leading to cleavage and degradation of PARP1 by CASP7 Human
62b4ffe300002385 Arginine ADP riboxanation of CASP4 by by S flexneri OspC3 that blocks CASP4 activity and pyroptosis Human
62b4ffe300002470 Ochratoxin A biosynthesis catabolism A niger
62b4ffe300002512 Ochratoxin biosynthesis in A carbonarius
62b4ffe300002544 Ilicicolin H Neonectria sp strain DH2
62b4ffe300002753 Poxvirus OPG106 inhibition of interferon gamma signaling Human Poxvirus
62b4ffe300002814 Poxvirus OPG204 inhibition of type I interferon signaling Human Poxvirus
62b4ffe300002896 Poxvirus OPG043 inhibition of host PKR Human Poxvirus
62b4ffe300002959 Aflaroxin Aspergillus parasiticus
62b4ffe300003074 Poxvirus OPG029 inhibition of host TBK1 adaptor TANK Human Poxvirus
62b4ffe300003248 Poxvirus OPG029 inhibition of host HDAC4 STAT2 Human Poxvirus
62b4ffe300003382 Poxvirus OPG038 inhibition of host CD80 CD86 Human Poxvirus
62b4ffe300003618 Poxvirus OPG045 inhibition of host BAK mediated apoptosis Human Poxvirus
62b4ffe300003655 Zearalenone biosynthesis Gibberella zeae
62b4ffe300003679 Poxvirus OPG200 inhibition of host IKBKE mediated NF Kappa B Human Poxvirus
62b4ffe300003747 Response to IFN beta leading to JAK STAT activation Human
62b4ffe300004209 Terrequinone A biosynthesis Emericella nidulans
62b4ffe300004362 Poxvirus OPG193 interferon gamma decoy receptor Human Poxvirus
62b4ffe300004525 Regulation of the JAK STAT pathway by calmodulin in response to interferon beta Human
62b4ffe300004795 Insulin receptor signaling pathway 1 Mouse
62b4ffe300004953 Arginine ADP riboxanation of CASP3 by by C violaceum CopC that blocks CASP3 activity subsequent apoptosis and pyroptosis Human
62b4ffe300005014 Poxvirus OPG176 inhibition of hostTLR4 signaling Human Poxvirus
62b4ffe300005096 Poxvirus OPG022 inhibition of host IL18 signaling pathway Human Poxvirus
62b4ffe300005181 Poxvirus OPG003 inhibition of host NF kappa B pathway via NFKB1 Human Poxvirus
62b4ffe300005342 Poxvirus OPG179 inhibition of host NF kappa B via BTRC Human Poxvirus
62b4ffe300005389 Poxvirus OPG184 inhibition of host NF kappa B via KPNA2 Human Poxvirus
62b4ffe300005506 Poxvirus OPG182 inhibition of host NF kappa B via IRAK2 Human Poxvirus
62b4ffe300005623 HHV1 US3 inhibition of host TCR signaling via LAT Human Herpesvirus
62b4ffe300005697 HHV1 US3 inhibition of host RIG I signaling Human Herpesvirus
62b4ffe300005953 HHV1 US3 inhibition of host NF kappa B signaling via RELA Human Herpesvirus
62b4ffe300006001 HHV1 US3 inhibition of host IRF3 Human Herpesvirus
62b4ffe300006376 HHV1 UL37 inhibition of host RIG I signaling via RIG I deamidation Human Herpesvirus
62b4ffe300006474 B cell receptor signaling pathway 1 Mouse
62b4ffe300006559 Insulin receptor signaling pathway 2 Mouse
62d0afa500000132 Gluconeogenesis 2 Mouse
62d0afa500000298 Gluconeogenesis 3 Mouse
62d0afa500000472 Insulin receptor signalling pathway 3 Mouse
62d0afa500001077 Insulin like growth factor receptor signaling pathway 1 Mouse
62f58d8800000011 Inactivation of GSDMD by Protease 3C from Human enterovirus 71 EV71 Human
62f58d8800000378 Insulin like growth factor receptor signaling pathway 4 Mouse
62f58d8800001119 Insulin receptor recycling Mouse
62f58d8800001316 PIV5 V inhibition of STAT1 via DDB1 CUL4A Human Paramyxovirus
62f58d8800001500 Insulin processing 1 Mouse
62f58d8800001680 Gut Microbiota tryptophan metabolism Regulation of intestinal epithelial cell homesotasis by Indole AhR Human E coli
62f58d8800002184 positive regulation of insulin secretion involved in cellular response to glucose stimulus Mouse
62f58d8800002367 Protein import into peroxisomes of PTS1 containing proteins by the PEX5 receptor and recycling of the PEX5 receptor S cerevisiae
62f58d8800002485 Protein import into peroxisomes of PTS1 containing proteins by the PEX5 receptor and recycling of the PEX5 receptor Human
62f58d8800003012 Positive regulation of insulin secretion 2 Mouse
62f58d8800003277 Import of ATM into peroxisomes y in response to reactive oxygen species via the PEX5 dependent import pathway leading to PEX5 ubiquitination and pexophagy Human
62f58d8800003536 Protein import into peroxisomes of PTS2 containing proteins by the PEX7 receptor and isoform PEX5L of PEX5 Human
62f58d8800003672 Positive regulation of insulin secretion 3 Mouse
62f58d8800004064 Positive regulation of insulin secretion 4 Mouse
62f58d8800004529 Positive regulation of insulin secretion 6 Mouse
62f58d8800004803 Positive regulation of insulin secretion 7 Mouse
63a86a8600000221 positive regulation of transcription from RNA polymerase II promoter by glucose 1 Mouse
63a86a8600000288 positive regulation of transcription from RNA polymerase II promoter by glucose 2 Mouse
63a86a8600000489 TRIM22 NT5C2 regulation of RIGI via ubiquitination Human
63a86a8600000805 Positive regulation of transcription from RNA polymerase II promoter by glucose 3 Mouse
63a86a8600001202 DHX16 mediated viral RNA recognition and activation of RIGI Human
63a86a8600001386 Triglyceride biosynthetic process 1 Mouse
63a86a8600001720 The non canonical inflammasome mediated by Casp11 upon lipopolysaccharide binding Mouse
63a86a8600001865 Irgb10 Gm12250 mediates disruption of the pathogen membrane liberating ligands that are detected by inflammasomes Mouse
63c0ac2b00000008 The AIM2 inflammasome Human
63c0ac2b00000088 The AIM2 inflammasome Mouse
63c0ac2b00000267 IRGM governs the core autophagy machinery to conduct antimicrobial defense Human
63c0ac2b00000464 Zika virus inhibition of TBK1 via CEP63 binding and centrosome disorganization Human Zika virus
63c0ac2b00000506 Degradation of NMNAT2 via the PAM SKP1 FBXO45 MYCBP2 E3 ligase complex Human
63c0ac2b00000547 Staphylococcal HlgB activation of NF kappa B via AMFR and TAB3 Human Staphylococcus Aureus
63d320cd00000225 Activation of the AIM2 inflammasome in response to DNA damage Mouse
63d320cd00000317 Activation of the AIM2 inflammasome in neural cells shapes neurodevelopment Mouse
63d320cd00000399 Negative regulation of the AIM2 inflammasome by Ifi202 Mouse
63d320cd00001688 Response to ribosome stalling by GCN1 RNF14 and RNF25 leading to ubiquitination and degradation of EEF1A1 Human
63f809ec00000347 TRIM60 mediated inhibition of NF kappa B signaling via TAB2 SUMOylation Human
63f809ec00000512 Activity of the RQC complex via ubiquitination and degradation of incompletely synthesized nascent proteins by NEMF and LTN1 following ribosome dissociation Human
63f809ec00000560 Non canonical activity of the RQC complex via CAT tailing by NEMF that promotes degradation of incompletely synthesized nascent proteins by the DesCEND pathway Human
63f809ec00000635 Activity of the RQC complex via ubiquitination and degradation of incompletely synthesized nascent proteins by RQC2 and RKR1 LTN1 following ribosome dissociation S cerevisiae
63f809ec00000701 tRNA repair and recycling by ANKZF1 ELAC1 and TRNT1 following activity of the RQC complex in response to stalled ribosomes Human
63f809ec00001358 ARKL1 negatively negulates Epstein Barr virus reactivation by inhibiting JUN mediated transcription Human Epstein Barr virus
63f809ec00001734 TGF beta mediated inhibition of TAF7 via TRIM26
64c3044100000089 Skeletal muscle acetylcholine gated channel clustering 1 Mouse
64c3044100000125 Positive regulation of acetylcholine receptor transcription Mouse
64c3044100001787 Inhibition of cGAS STING signaling in the nucleus by BANF1 Human
64d5781900000111 Activation of cGAS STING signaling following acetylation by KAT5 Human
64d5781900000443 Inhibition of cGAS STING signaling in the cytosol by TREX1 Human
64d5781900000615 Activation of canonical mTORC1 following glycosylation of RPTOR by OGT in response to glucose sufficiency Human
64d5781900002033 Insulin mediated activation of the ARF6 RAC1 axis in neurite outgrowth Human
65bc474400000537 Regulation of Hippo signaling by MAP4K4 Human
65bc474400000955 Negative regulation of Hippo signaling by STRIPAK complex via STRN4 MAP4K4 Human
65c57c3400000000 Inhibition of the GDF15 GFRAL aversive signaling pathway following cleavage of GFRAL by MMP14 Human
65c57c3400000100 Resolution of protein DNA cross links by HMCES BRIP1 FANCJ and SPRTN Human
65c57c3400000173 The MSL complex composed of MSL1 MSL2 MSL3 and KAT8 mediates acetylation of histone H4 at Lys 16 H4K16ac Human
65c57c3400000359 Dosage compensation in male Drosophila by the MSL complex composed of mle msl 1 msl 2 msl 3 and mof D melanogaster
65c57c3400001115 Inhibition of SMDT1 EMRE and MCU following cleavage by the m AAA protease complex composed of AFG3L2 and SPG7 Human
65c57c3400001478 Negative regulation of Hippo signaling by SLMAP STRIPAK complex Human
65c57c3400002539 The CRL5 ASB11 complex mediates ubiquitination and degradation of DIRAS2 Human
65c57c3400002666 Role of CD53 in T cell receptor signaling pathway Human
65d7e4ac00000022 CARD9 regulation by TRIM62 USP15 Human
65d7e4ac00000082 DUSP22 inhibition of TCR signaling via UBR2 inhibition Human
65d7e4ac00001282 Thrombospondin 1 CD36 inhibition of angiogenesis in endothelial cells Human
65d7e4ac00001363 Mitochondrial calcium uptake by the uniplex complex composed of SMDT1 EMRE MICU1 MICU2 and MCU Human
65d7e4ac00001732 Activation of GPR75 by CCL5 in neurons Human
65d7e4ac00001800 RUFY1 mediates early endosome to Golgi transport Human
65d7e4ac00002167 Glycogen biosynthetic process Dmel
65d7e4ac00002290 Glycogen catabolic process Dmel
65d7e4ac00002427 MICA NKG2D mediated NK cell cytotoxicity Human
65d7e4ac00002435 MICU3 promotes mitochondrial calcium uptake by MCU in the central nervous system Human
65d7e4ac00002808 MCUB inhibits mitochondrial calcium uptake by the uniplex complex composed of SMDT1 EMRE MICU1 MICU2 and MCU to prevent calcium overload Human
65f3ae5c00000111 Ufmylation pathway Human
65f3ae5c00000585 Ufmylation of CYB5R3 promotes reticulophagy and CYB5R3 degradation Human
65f3ae5c00001022 UFL1 negatively regulates T cell activation by mediating ufmylation of PDCD1 PD 1 Human
65f3ae5c00002132 Control of GABAAR clustering to GABAergic synapses by Gephyrin Human
65f3ae5c00002208 Positive regulation of glycogen catabolic process 1 Mouse
65f3ae5c00002270 Positive regulation of glycogen catabolic process 2 Mouse
66a3e0bb00000156 Positive regulation of cholesterol biosynthesis by PAQR3 by anchoring SREBF1 SCAP complex to the Golgi Human
66a3e0bb00000443 Positive regulation of cholesterol biosynthesis by PAQR3 by anchoring SREBF2 SCAP complex to the Golgi Human
66a3e0bb00001036 IGF1 mediated signaling via IGF1R receptor Human
66a3e0bb00001159 Signaling by Adrenomedullin mediated by ADM ligand activating CALCRL RAMP2 receptor complex Human
66a3e0bb00001555 Signaling by Adrenomedullin mediated by ADM ligand activating CALCRL RAMP3 receptor complex Human
66a3e0bb00001633 Signaling by Adrenomedullin mediated by ADM2 ligand activating CALCRL RAMP3 receptor complex Human
66a3e0bb00001687 Signaling by Calcitonin CGRP mediated by CALCA CGRP1 ligand activating CALCRL RAMP1 receptor complex Human
66a3e0bb00001742 Signaling by Calcitonin CGRP mediated by CALCB CGRP2 ligand activating CALCRL RAMP1 receptor complex Human
66a3e0bb00001796 Signaling by Amylin mediated by IAPP ligand activating CALCR RAMP1 AMYR1 receptor complex Human
66a3e0bb00002104 ITPRIPL1 is a ligand of CD3E that negatively regulates TCR signaling pathway Human
66a3e0bb00002740 TMEFF1 restricts herpes simplex virus 1 HHV 1 infection in the brain by blocking the association between NECTIN1 and the viral envelope glycoprotein D Human
66a3e0bb00002776 TMEFF1 restricts herpes simplex virus 1 HHV 1 in the brain by blocking the association between MYH9 and the viral envelope glycoprotein B Human
66a3e0bb00002793 TMEFF1 restricts herpes simplex virus 1 HHV 1 in the brain by blocking the association between MYH10 and the viral envelope glycoprotein B Human
66a3e0bb00002890 Thrombopoeitin mediated signaling pathway Human
66a3e0bb00002988 pteridine containing compound metabolic process GO 0042558
66b5638000000056 GDP L fucose salvage Mouse
66b5638000000102 PVR CD226 mediated NK cell cytotoxicity Human
66b5638000000624 Activation of the integrated stress response via activation of EIF2AK3 PERK in response to unfolded protein response Human
66b5638000000739 Inhibition of the PERK mediated unfolded protein response by HSPA5 BiP in absence of stress Human
66b5638000000808 Ubiquitination and degradation of NFE2L2 NRF2 by KEAP1 in absence of stress Human
66b5638000000873 EIF2AK3 PERK phosphorylates NFE2L2 NRF2 in response to unfolded protein response preventing the ubiquitination of NFE2L2 NRF2 by KEAP1 Human
66b5638000001291 NECTIN2 CD226 mediated NK cell cytotoxicity Human
66b5638000001589 Activation of the integrated stress response via activation of EIF2AK3 PERK in response to unfolded protein response promotes expression of COX7A2L SCAF1 increasing formation of respiratory chain supercomplexes Human
66b5638000001665 Signaling by Calcitonin mediated by CALCA CT ligand activating CALCR RAMP2 AMYR2 receptor complex Human
66b5638000001719 AKT1 inhibits EIF2AK3 PERK Human
66b5638000001772 Signaling by Calcitonin mediated by CALCA CT ligand activating CALCR receptor Human
66b5638000001825 Signaling by Amylin mediated by IAPP ligand activating CALCR receptor Human
66b5638000001968 PVR TIGIT pair inhibits NK cell mediated cytotoxicity Human
66b5638000002273 GRIM1 activates GRID2 via GNAQ in Purkinje cells Human
66b5638000002528 GRIM1 activates GRID1 via GNAQ in dopamine neurons Mouse
66b5638000002630 GRIM1 activates GRID1 via GNAQ in dopamine neurons Human
66b5638000002701 IL13RA2 mediated alternative IL13 pathway leading to TGFB1 production Human
66c7d41500000163 Signaling by Calcitonin CGRP mediated by CALCA CGRP1 ligand activating CALCR RAMP1 AMYR1 receptor complex Human
66c7d41500000427 Zika virus NS5 inhibition of STAT2 signaling via ZSWIM8 Human
66c7d41500000544 CAAX box protein maturation 1 Mouse
66c7d41500000715 CLEC12A acts as an inhibitor of neutrophil activation Human
66c7d41500000841 heme biosynthetic process GO 0006783
66c7d41500002088 ergosterol biosynthetic process
66c7d41500002513 DDX39A inhibition of immune related RNA export to the cytoplasm Human
66f5faaa00000112 TRAF6 and HUWE1 catalyze branched linked polyubiquitination that promote NF kappa B signaling Human
66f5faaa00001204 Retinoid Metabolic Process 1 Mouse
568b0f9600000284 Antibacterial innate immune response in the intestine via MAPK cascade C elegans
600ced8500002343 BMP9 signaling pathway Human
613aae0000000011 SP ANN SEC14L1
613aae0000000040 cGAS Sting pathway Drosophila
613aae0000000341 cobalamin transport 2 distribution to tissues Mouse
613aae0000000500 cobalamin metabolic process 3 methylation of cobalamin Mouse
613aae0000000579 SP ANN TPPP
613aae0000000813 Liver apoptosis regulation by CASP6 Human
613aae0000000885 SP ANN PTPRM
613aae0000001005 SP ANN RECQL5
617b481400000389 KAT5 regulation of the cytoskeleton by acetylation of proteins Human
617b481400000460 KAT5 involvement in DNA repair via homologous recombination Human
617b481400000521 KAT5 involvement in nucleotide excision repair Human
617b481400000559 KAT5 regulation of lipid droplet disassembly Human
617b481400000672 KAT5 chromatin localization Human
617b481400000793 KAT5 autoacetylation and deacetylation by HDAC3 and SIRT1 Human
617b481400000995 Epidermal growth factor receptor signaling pathway 1 Mouse
617b481400003575 SP RNF169
622aace900000443 Fructose catabolic process Mouse
622aace900000790 Galactose catabolic process via UDP galactose
622aace900000962 Pentose phosphate shunt 1 Mouse
622aace900001389 Pentose phosphate shunt 2 Mouse
623d156d00000029 Glycogen biosynthetic process Mouse
623d156d00000290 IL4 mediated signaling pathway human
623d156d00000340 IL3 mediated signaling pathway Human
623d156d00000673 IL5 mediated signaling pathway Human
623d156d00000699 Glycogen catabolic process 1 Mouse
623d156d00000752 Glycogen catabolic process 2 Mouse
623d156d00000939 Glycogen catabolic process 3 Mouse
626b20c100000025 IL9 mediated signaling pathway Human
626b20c100000185 Glycosaminoglycan biosynthetic process linker formation Mouse
626b20c100000443 Regulation of gluconeogenesis by TOX4 Mouse
626b20c100000681 IL10 mediated signaling pathway Human
627d95ee00000024 IL12 mediated signaling pathway Human
627d95ee00000044 3 phosphoadenosine 5 phosphosulfate biosynthetic process Mouse
627d95ee00000275 Heparan sulfate proteoglycan catabolic process Mouse
627d95ee00000472 IL15 signaling pathway Human
627d95ee00000757 Regulation of CGAS activity by ZDHHC18 Human
627d95ee00000909 Regulation of CGAS by PCBP2 Human
627d95ee00000955 Chondroitin sulfate catabolic process Mouse
627d95ee00001405 Il17A mediated signaling pathway Human
627d95ee00001943 Activation of PARP1 activity by HPF1 during DNA repair Human
627d95ee00001988 Regulation of Parp1 activity by Cgas Setd7 and Riox1 Mouse
627d95ee00002030 Activation of PARP2 activity by HPF1 during DNA repair Human
627d95ee00002159 Xenopus trio and cdh11 in development and neural cell migration
632cf60a00000169 HHV1 ICP0 modulation of interferon production via MORC3 degradation Human Herpesvirus
632cf60a00000788 USP20 mediated STING deubiquitination leading to STING stabilisation Human
633b013300000089 Positive regulation of insulin secretion 11 Mouse
633b013300000306 Tricarboxylic acid cycle 1 Mouse
633b013300001238 Pyruvate catabolic process 1 Mouse
633b013300001469 Pyruvate catabolic process 2 Mouse
633b013300001722 TRIM27 mediated inhibition of starvation induced autophagy via ubiquitination of STK38L and ULK1 Human
635b1e3e00000382 Xylulose 5 Phosphate biosynthetic process 1 Mouse
635b1e3e00000433 Xylulose 5 Phosphate biosynthetic process 2 Mouse
635b1e3e00001811 The NLRP3 inflammasome Human
635b1e3e00002003 Inhibition of GSDMD mediated pyroptosis by M tuberculosis PtpB phosphatase that alters membrane phospholipid composition Human and M tuberculosis
635b1e3e00002004 Activation of the NLRP3 inflammasome by MAPK8 JNK1 and BRCC3 Human
636d9ce800000147 Cellular response to glucagon stimulus Mouse
636d9ce800001192 DCAF12 controls MOV10 during T cell activation Human
636d9ce800001222 DCAF12 controls MOV10 during spermatogeneis Human
636d9ce800002041 Positive regulation of gluconeogenesis 1 Mouse
639bc18f00000090 Isg12a K6 ubiquitination by TRIM21 leading to pyroptosis Human
639bc18f00000430 Negative regulation of glycolytic process through fructose 6 phosphate 2 Mouse
641ce4dc00000050 NOD2 signaling in response to muramyl dipeptide MDP leading to NF kappa B and MAPK kinase activation Human
641ce4dc00000214 NOD1 signaling in response to gamma D glutamyl meso diaminopimelic acid iE DAP leading to NF kappa B and MAP kinase activation Human
641ce4dc00000430 NOD2 localization to the plasma membrane following palmitoylation by ZDHHC5 Human
641ce4dc00000586 UBL7 TRIM21 mediated ubiquitination of MAVS leading to type I interferon production Human
641ce4dc00000914 Activation of Nf kappa B via ubiquitination and degradation of the NF kappa B inhibitor Human
641ce4dc00001047 Generation of NFKB1 p50 subunit of Nf kappa B via limited processing by the KPC1 complex RNF123 leading to NF kappa B inhibitor Human
645d887900000340 Coenzyme A biosynthetic process 1 Mouse
645d887900000439 Contracted muscle secreted FN1 activates liver autophagy via hepatic Itga5 Itgb1 integrin receptor signaling Mouse
645d887900000671 Osteocalcin bglap hormone produced by osteoblasts binds Gprc6a receptor and regulates testosterone biosynthesis and male fertility Mouse
645d887900000706 Smog GPCR signaling epithelial tube formation D mel
645d887900000999 BMP7 signaling leading to osteoblast differentiation Human
645d887900001077 Cell type specific p53 independent mitotic G2 DNA damage checkpoint signaling mediated by CREB3L1 in astrocytes Mouse
645d887900001323 14 3 3 sequestering of ZNRF2 E3 ligase leading to ATP1A1 activity at plasma membrane Human
645d887900001414 ZNFR1 mediated TLR4 signaling pathway via CAV1 ubiquitination and degradation Human
645d887900001551 Coenzyme A catabolic process 2 Mouse
646ff70100000391 Canonical mTORC1 signaling Human
646ff70100000611 Ubiquitination of RagA RRAGA by RNF152 inhibits the mTORC1 signaling Human
646ff70100001312 Inhibition of the canonical mTORC1 signaling by the GATOR1 complex Human
646ff70100001877 Inhibition of the canonical mTORC1 signaling via ubiquitination and degradation of LAMTOR1 by UBE3A Human
646ff70100002308 SMAD6 arginine methylation inhibits SMAD1 signaling Human
646ff70100002557 Negative regulation of autophagy via phosphorylation of ULK1 by canonical mTORC1 signaling Human
646ff70100003125 Inhibition of the canonical mTORC1 signaling by NLK in response to osmotic stress Human
646ff70100004025 Activation of the canonical mTORC1 signaling via non catalytic deubiquitination of RPTOR by OTUB1 Human
646ff70100004220 Inhibition of the canonical mTORC1 signaling by AKT1S1 PRAS40 in absence of insulin Human
646ff70100004606 Inhibition of the canonical mTORC1 signaling by TSC2 in response to starvation Human
646ff70100004848 Activation of the canonical mTORC1 signaling in response to insulin via phosphorylation and inhibition of TSC2 Human
646ff70100004973 USP38 Lys 33 to Lys 48 transition on TBK1 leading to its degratdation Human
646ff70100005032 HCMV UL138 substains STAT1 activation during viral latency Human Cytomegalovirus
646ff70100005137 IL33 signaling pathway Human
648d0dc100000022 SUCNR1 in adipocytes controls energy homeostasis by modulating circadian clock and LEP expression Mouse
648d0dc100000867 Phosphorylation of DEPTOR by MAPK3 ERK1 promotes DEPTOR deubiquitination by USP7 and enhanced protein stability Human
648d0dc100001272 Inhibition of the non canonical mTORC1 signaling following phosphorylation of FNIP1 by AMPK in response to mitochondrial stress Human
653b0ce600000202 BRD3 and lncRNA DIGIT form phase separated condensates to induce endoderm cell differentiation Human
653b0ce600000382 TAX1BP1 mediated degradation of MAVS by E3 ligase ITCH Human
653b0ce600000432 TRIM32 TAX1BP1 dependent selective autophagic degradation of TICAM1 Human
653b0ce600000721 A checkpoint mediated by ATR that restricts activation of CDK1 during S phase Human
653b0ce600001230 KSHV ORF57 inhibition of host PKR Human HHV8
653b0ce600001283 KSHV ORF57 inhibition of host P body formation Human HHV8
654d809000000010 Regulation of aggrephagy via palmitoylation and depalmitoylation of SQSTM1 by ZDHHC19 and LYPLA1 respectively Human
654d809000000112 SQSTM1 is involved in aggrephagy by mediating recruitment of ubiquitinated proteins to autophagosomes Human
654d809000000248 Regulation of aggrephagy via phosphorylation of SQSTM1 by CK2 Human
662af8fa00000002 BTRC is ubiquitinated and degraded by a Cul5 RING ubiquitin ligase complex Human
662af8fa00000408 ubiquinone metabolic process GO 0006743
662af8fa00002225 Gsdmd palmitoylation by Zdhhc5 and Zdhhc9 promotes pyroptosis Mouse
662af8fa00002332 CD28 GRB2 axis leading to RAS activation Human
662af8fa00002572 Activation of the non canonical inflammasome mediated by Casp11 upon lipopolysaccharide binding can lead to blood brain barrier breakdown Mouse
662af8fa00002657 Activation of the non canonical inflammasome mediated by CASP4 upon lipopolysaccharide binding can lead to blood brain barrier breakdown Human
662af8fa00002877 TRAIL TRAILR1 interaction leading to apoptosis
663d668500000226 VIF mediated inhibition of STING by PTPN6 Human HIV
663d668500000596 oxidative phosphorylation GO 0006119
663d668500001246 Pyroptotic cell death mediated by GSDMD and NINJ1 Human
663d668500001492 TRAIL TRAILR2 interaction leading to apoptosis
663d668500001911 purine nucleobase metabolic process GO 0006144
663d668500002178 phosphatidylinositol phosphate phosphatidylinositol biosynthetic process GO 0006661 GO 0043647
663d668500002302 canonical glycolysis GO 0061621
663d668500003144 TGFB1 mediated signaling pathway Human
663d668500003182 TGFB2 mediated signaling pathway Human
663d668500003232 TGFB3 mediated signaling pathway Human
666b894f00000196 CD93 Multimerin 2 β1 integrin complex function in angiogenesis Human
6086f4f200000223 canonical Wnt signaling pathway via wg fz2 D mel
6205c24300000050 SIRT6 inactivation by lncPRESS1 RNA Human
6205c24300000330 Microtubule polyglutamylation regulation Human
6205c24300000880 Regulation of cholesterol biosynthesis by SREBP SREBF1 and SREBF2 and retention by the SREBP SCAP complex Human
6205c24300001663 IL2 signaling pathway Human
6258b8f300000188 Chondroitin sulfate biosynthetic process 1 chondroitin 6 sulfate proteoglycans Mouse
6258b8f300000398 Heparan sulfate proteoglycan biosynthetic process Mouse
6348a65d00000093 USP20 inhibition of NF kappa B signaling via TRAF6 deubiquitination Human
6348a65d00000594 Granzyme mediated GZMA activation of pyroptosis GSDMB isoform 4 Human
6348a65d00000661 Cytotoxic T cell pyroptosis mediated by GSDMB isoform 1 in response to infection by Gram negative bacteria and its inhibition by S flexneri IpaH7 8 Human and S flexneri
6348a65d00000724 Regulation by IL22 and Reg3g of allergic airway inflammation Mouse
6348a65d00000848 Regulation by IL22 and REG3A of allergic airway inflammation Human
6348a65d00001191 Nociceptor derived Reg3g prevents endotoxic death by targeting kynurenine pathway in microglia Mouse
6348a65d00001727 Negative regulation of inflammatory response to wounding by REG3A Human
6348a65d00002174 USP44 mediated FOXP3 deubiquitination leading to regulatory T cell differentiation Human
6348a65d00002236 USP44 mediated deubiquitination of CDC20 controlling anaphase initiation Human
6348a65d00002600 Negative regulation of white adipogenesis by OVOL2 Human
6348a65d00002622 Ascorbic acid biosynthetic process 1 Mouse
6413ac9800000256 MYD88 dependent TLR4 signaling pathway leading to autophagy activation Human
6413ac9800000654 MYD88 independent TLR4 signaling pathway leading to interferon production Human
6446bfcb00000006 Triglyceride biosynthetic process 2 Mouse
6446bfcb00000319 Negative regulation of epidermal growth factor receptor signaling pathway 1 Mouse
6446bfcb00000544 Negative regulation of epidermal growth factor receptor signaling pathway 2 Mouse
6446bfcb00001000 Positive regulation of epidermal growth factor receptor signaling pathway 1 Mouse
6446bfcb00001208 Thiamine diphosphate biosynthetic process 1 Mouse
6446bfcb00001243 Thiamine diphosphate biosynthetic process 2 Mouse
6446bfcb00001774 Autophagosome assembly Human
56170d5200000012 kctd10 in heart development PMID 24430697
60418ffa00000327 Xanthine catabolic process Mouse
60418ffa00000414 Adenosine catabolic process Mouse
60418ffa00000811 Inosine catabolic process Mouse
60418ffa00001019 NLRP3 inflammasome in pyroptosis via nlrp3 caspa caspb etc D rerio
60418ffa00001124 Hypoxanthine catabolic process Mouse
60418ffa00001200 Guanine catabolic process Mouse
60418ffa00001258 Deoxyadenosine catabolic process Mouse
60418ffa00001536 Deoxyguanosine catabolic process Mouse
60418ffa00001643 Deoxyinosine catabolic process Mouse
60897d8500000494 IMP salvage Mouse
60897d8500000531 AMP salvage Mouse
61283a3000000217 cobalamin metabolic process 1 adenosylation of cobalamin Mouse
62183af000000536 DNA damage sensor activity of SIRT6 and its regulation by SIRT1 Human
62900b6400000022 Mono ADP ribosylation of ribosome subunits by PARP16 Human
62900b6400000076 Histone poly ADP ribosylation of histone H2B at Glu 35 by Parp1 that prevents phosphorylation at of histone H2B at Ser 36 by Prkaa1 Mouse
62900b6400000500 Regulation of ACLY by acetylation by PCAF KAT2B and ubiquitination by UBR4 Human
62900b6400001630 PTEN in excitatory hippocampal synapse long term depression Human
62900b6400002267 Casp7 activates Smpd1 to repair Gasdermin pores in intestinal epithelial cells Mouse
62900b6400002353 Casp7 activates Smpd1 to repair perforin pores in hepatocytes Mouse
62900b6400002552 Cobalamin transport into enterocytes Mouse
62900b6400002879 Dermatan sulfate catabolic process Mouse
63894f2500000740 FIP200 ubiquitination by TRIM21 leading to autophagy inhibition Human
63894f2500000870 Liquid liquid phase separation of FXR1 drives translation of mRNAs and regulation of FXR1 by ubiquitination and phosphorylation Human
63894f2500001748 FRM1 binds N6 methyladenosine m6A containing mRNAs and promotes their nuclear export Human
63894f2500001789 Fmr1 binds N6 methyladenosine m6A containing mRNAs and promotes their nuclear export Mouse
63894f2500001894 ARRDC4 mediated activation of MDA5 through K63 ubiquitination by TRIM65 Human
63894f2500002043 Positive regulation of glycolytic process 1 Mouse
65288b2200000194 STING1 acts as a proton channel and promotes autophagosome assembly Human
65288b2200000496 Regulation of CGAS activity via palmitoylation and depalmitoylation by ZDHHC9 and LYPLAL1 respectively Human
65288b2200000643 STING1 trafficking from the endoplasmic reticulum and the ERGIC following phosphorylation by MAP3K7 TAK1 and interaction with STEEP1 Human
65288b2200001166 TRIM55 and TRIM21 mediated inhibition of NFKB2 Human
65288b2200001218 USP9X TRIM32 modulation of IQCB1 during G1 S Human
65288b2200001267 USP9X TRIM32 modulation of IQCB1 during G2 M Human
67086be200000363 cardiolipin metabolic process GO 0032048 Spom
67086be200001578 Negative regulation of BNIP3 and BNIP3L via PPTC7 and FBXL4 Human
67086be200001601 Fertilization complex allows sperm egg recognition during fertilization Human
67086be200002266 sphingolipid biosynthetic process GO 0030148
67086be200002592 Retinoid Metabolic Process 3 Mouse
67086be200002705 Retinoid Metabolic Process 4 Mouse
6494e2e900000187 TRAF7 modulation of NF kappa B via IKBKG and NEMO K 29 ubquitination Human
6494e2e900001469 Mpeg1 perforin 2 forms a pore for to deliver antigens for cross presentation Mouse
6494e2e900001496 MPEG1 perforin 2 forms a pore for to deliver antigens for cross presentation Human
6494e2e900002018 Glyceraldehyde 3 phosphate biosynthetic process 1 Mouse
6494e2e900002525 SUCNR1 in adipocytes controls energy homeostasis by modulating circadian clock and LEP expression Human
665912ed00000015 tricarboxylic acid cycle GO 0006099
665912ed00000192 GPI anchor biosynthetic process GO 0006506
665912ed00000459 dolichol linked oligosaccharide biosynthetic process GO 0006488
665912ed00000652 pericentric heterochromatin formation GO 0031508
665912ed00001983 subtelomeric heterochromatin formation GO 0031509
665912ed00002626 nitrogen cycle metabolic process GO 0071941
5745387b00001516 Canonical glycolysis 1 Mouse
6246724f00000078 Glucuronate catabolic process to xylulose 5 phosphate Mouse
6246724f00000283 Regulation of the mTORC1 signaling via ubiquitination and deubiquitnation of SESN2 by RNF167 and STAMBPL1 Human
6246724f00000369 Regulation of the mTORC1 signaling via ubiquitination and degradation of CASTOR1 by RNF167 Human
6246724f00000549 Renin angiotensin pathway Human
6246724f00000675 IL7 mediated signaling pathway Human
6246724f00000763 TSLP mediated signaling pathway Human
6246724f00001645 hyaluronan biosynthetic process Mouse
6246724f00001700 Hyaluronan catabolic process Mouse
6438950a00000032 Human metapneumovirus M2 2 inhibition of IRF7 Human Metapneumovirus
6438950a00000074 Human metapneumovirus M2 2 inhibition of RIGI MAVS signaling Human Metapneumovirus
6438950a00000624 Activation of the WNK1 SPAK OSR1 kinase cascade in response to hyperosmotic stress leading to promote ion influx and prevent ion efflux Human
6438950a00000714 Regulation of ion transport in the distal nephron by WNK4 Human
6690711d00001771 AARS1 mediates lactylation of YAP1 and TEAD1 promoting activation of Hippo signaling Human
6690711d00001806 SIRT1 mediates delactylation of YAP1 and TEAD1 promoting inactivation of Hippo signaling Human
6690711d00002607 ANG tRNA ribonuclease activity inhibits translation in response to stress Human
6690711d00002652 RNH1 inhibits the tRNA ribonuclease activity of ANG in the cytoplasm in absence of stress Human
6690711d00002821 tryptophan biosynthetic process GO 0000162
6690711d00002904 L histidine biosynthetic process GO 0000105
64e7eefa00000854 Tumor necrosis factor mediated signaling pathway 1 Mouse
64e7eefa00001233 Extrinsic apoptotic signaling pathway via death domain receptors 1 Mouse
64e7eefa00001258 Inhibition of ALKBH5 RNA demethylase activity by sumoylation in response to reactive oxygen species Human
64e7eefa00001299 RBM33 binds N6 methyladenosine m6A containing mRNAs and promotes their demethylation by ALKBH5 RNA demethylase Human
64e7eefa00001978 ALKBH5 is involved in paraspeckle assembly and is regulated by acetylation and deacetylation by KAT8 and HDAC7 respectively Human
5966411600000170 Intestinal smooth muscle cell differentiation via foxo1a mir145 tgfr1b ltbp3 zeb1a D rerio
6197061700000593 ERBB2 EGFR signaling pathway 1 Mouse
6197061700001485 Silencing of fetal hemoglobin by ZNF410 Human
6197061700001622 Epidermal growth factor receptor signaling pathway 2 Mouse
6197061700001643 Epidermal growth factor receptor signaling pathway 3 Mouse
6197061700002226 ERBB2 ERBB4 signaling pathway 2 Mouse
6197061700002397 Fatty acid transport by CD36 via LYN mediated endocytosis Human
6482692800000198 Regulation of the canonical mTORC1 signaling via ubiquitination and deubiquitination of RHEB by RNF152 and USP4 respectively Human
6482692800000330 Regulation of the canonical mTORC1 signaling via deubiquitination of RHEB by ATXN3 in response to starvation Human
6482692800000498 Activation of the canonical mTORC1 signaling by GPR155 LYCHOS in response to cholesterol influx Human
6482692800000701 Activation of the canonical mTORC1 signaling by BMT2 SAMTOR in response to S adenosyl L methionine influx Human
6482692800001029 Activation of the canonical mTORC1 signaling by GATOR2 which inactivates GATOR1 in response to abundant amino acids Human
6482692800001393 Biotin Metabolic Process 1 Mouse
6482692800001514 Inactivation of the canonical mTORC1 signaling via phosphorylation of WDR24 by AMPK in response to glucose starvation Human
6482692800001739 Inhibition of the canonical mTORC1 signaling via phosphorylation of RPTOR by AMPK in response to glucose starvation Human
6482692800002523 Molybdopterin Cofactor Biosynthetic Process 1 Mouse
6482692800002614 Non canonical mTORC1 signaling leading to TFEB and TFE3 phosphorylation and inactivation Human
6516135700000211 Tumor necrosis factor mediated signaling pathway 2 Mouse
6516135700000380 Heme A biosynthetic process Mouse
6516135700000961 Heme O biosynthetic process Mouse
6516135700001077 Heme B biosynthetic process Mouse
6606056e00000234 CD69 OxydizedLDL pair leading to PD 1 expression in T cells Human
6606056e00000282 LGALS1 CD69 pair involved in negative regulation of T helper 17 cell lineage Human
63e5937500000284 18S rRNA degradation in response to ribosome collision by HEL2 leading to ubiquitination of RPS3 uS3 by MAG2 RSP5 and HEL2 and rRNA degradation S cerevisiae
6606056e00001890 Activation of mitophagy in response to mitochondrial damage via activation of EIF2AK1 HRI by DELE1 Human
63e5937500000106 Activation of the GCN2 mediated signaling by GCN1 in response to ribosome collisions and inhibition of GCN2 by HEL2 S cerevisiae
6606056e00000903 Activation of the integrated stress response via activation of EIF2AK1 HRI by DELE1 in response to mitochondrial stress Human
62e3212700001956 Activation of the NLRP1 inflammasome by isoform ZAKalpha of MAP3K20 in response to UV B irradiation and ribotoxic stress Human
63e5937500000215 Activation of the No Go decay NGD pathway in response to ribosome collision by HEL2 leading to ubiquitination of RPS7 eS7 recruitment of CUE2 and mRNA degradation S cerevisiae
63e5937500000591 Activation of the ribosome quality control by ZNF598 in response to ribosome collisions leading to ubiquitination of RPS20 us10 and ribosome dissociation by the RQT complex composed of ASCC2 and ASCC3 Human
6606056e00001371 APP clearance through CLU TREM2 interaction Human
66187e4700003150 adenylate cyclase activating G protein coupled receptor signaling pathway GO 0007189
6606056e00002011 CD72 and BCR co stimulation by sn RNP self antigen Human
63e5937500001279 Extraction of mRNA from stalled ribosomes by the SKI complex leading to recruitment of the PELO HBS1L complex that binds to stalled ribosomes followed by ribosome dissociation by ABCE1 Human
66187e4700002129 Feedback regulation of erythropoietin mediated signaling via ubiquitination and degradation of EPOR by the ECS SOCS2 complex Human
66187e4700001644 Feedback regulation of growth hormone receptor signaling pathway via ubiquitination and degradation of GHR by the ECS SOCS2 complex Human
66187e4700003043 GDP mannose biosynthetic process from glucose Mouse
6606056e00002524 HIV 1 Vif protein hijacks a cullin 5 RING E3 ubiquitin protein ligase to mediate ubiquitination and degradation of APOBEC3G Human
65039e8700000196 HTATSF1 and TOPBP1 promote RPA RAD51 exchange in double strand break repair via homologous recombination Human
66187e4700002881 IFNA1 CR2 role in B cell ISGs induction Human
63e5937500001029 Inhibition of IFNB1 translation initiation by EIF4E2 in response to viral infection Human Sars CoV 2
66187e4700002704 Inhibition of reelin signaling via ubiquitination and degradation of DAB1 by the ECS SOCS7 complex in the cortical plate of the developing cerebral cortex Human
62e3212700000469 Insulin like growth factor receptor signaling pathway 2 Mouse
62e3212700000746 Insulin like growth factor receptor signaling pathway 3 Mouse
6606056e00000767 ITCH and UBR5 catalyzed branched linked polyubiquitination of TXNIP Human
66187e4700001744 meiotic cohesion protection in anaphase I GO 1990813
66187e4700001274 N6 methyladenosine modified lncRNA ARHGAP5 AS1 stabilises CSDE1 and coordinates oncogenic RNA regulons in hepatocellular carcinoma PMID 36354136 Human
63e5937500000487 Negative regulation of inflammatory response to wounding by Reg3g Mouse
65039e8700000055 Phosphorylation mediated interactions with TOPBP1 couples TP53BP1 and 9 1 1 in DNA damage checkpoint Human
62e3212700001890 Regulation of energy homeostasis by OTUD3 Human
6606056e00001308 Retinoic acid binds and activates RARA and RXRA nuclear receptors Human
66187e4700001573 RNA capping GO 0036260
5e72450500004237 SARS COV2 cycle
5e72450500004019 SARS COV2 HOST
66187e4700002599 SECTM1 CD7 interaction leading to cytokine production upon T cell activation Human
66187e4700002284 septation initiation signaling GO 0031028
66187e4700001781 silent mating type cassette heterochromatin assembly GO 0030466
66187e4700000246 The CRL5 ASB9 complex mediates ubiquitination and degradation of CKB Human
66187e4700000318 The CRL5 ASB11 complex mediates ubiquitination and degradation of BIK in response to endoplasmic reticulum stress Human
66187e4700002082 The erythropoietin mediated signaling pathway Human
66187e4700001597 The growth hormone receptor signaling pathway Human
66187e4700002778 The reelin signaling pathway Human
6606056e00001462 TREM2 activated by APOA1 Human
6606056e00001507 TREM2 activated by APOA2 Human
65039e8700001110 TRIM69 activation of STK3 by ubiquitination leading to centrosome separation Human
6606056e00001745 UBR4 and KCMF1 ubiquitinate arginylated proteins in response to oxidative stress leading to degradation of ubiquitinated proteins in autophagosomes Human
6606056e00000576 UBR5 ubiquitinates ligand bound VDR when VDR is not associated with Nuclear receptor coactivators NCOAs Human
60e7989d00000165 dTMP biosynthetic process1A Mouse
60e7989d00000281 UDP biosynthetic process Mouse
60e7989d00001485 Tetrahydrofolate interconversion 1a Mouse
66e382fb00000178 Signaling by Vasoactive Intestinal Peptide VIP mediated by VIPR1 receptor Human
66e382fb00000254 Signaling by Vasoactive Intestinal Peptide VIP mediated by VIPR2 receptor Human
66e382fb00000408 Signaling by PACAP ADCYAP1 mediated by VIPR1 receptor Human
66e382fb00000449 Signaling by PACAP ADCYAP1 mediated by VIPR2 receptor Human
66e382fb00000583 Signaling by PACAP ADCYAP1 mediated by PAC1R ADCYAP1R1 receptor Human
66e382fb00002105 BMP8A role in spermatogenesis via SMAD1 SMAD5 and SMAD9 Human
66e382fb00002243 BMP8B role in adipocyte differentiation inhibition Human
66e382fb00002293 Signaling by Secretin SCT mediated by SCTR receptor Human
MGI MGI 109482 Cacna1a MGI MGI 109482
YeastPathways GLUCONEO PWY 1 gluconeogenesis I imported from Saccharomyces Genome Database
YeastPathways P4 PWY 1 superpathway of threonine and methionine biosynthesis imported from Saccharomyces Genome Database
YeastPathways PWY3O 20 folate polyglutamylation imported from Saccharomyces Genome Database
YeastPathways PWY3O 4158 superpathway of NAD biosynthesis imported from Saccharomyces Genome Database
YeastPathways PWY 5084 2 oxoglutarate decarboxylation to succinyl CoA imported from Saccharomyces Genome Database
YeastPathways TCA EUK PWY TCA cycle aerobic respiration imported from Saccharomyces Genome Database
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GO CAM annotation guidelines README