GO-CAM Gallery¶

FIG-654d809000000010-Regulation_of_aggrephagy_via_palmitoylation_and_depalmitoylation_of_SQSTM1_by_ZDHHC19_and_LYPLA1__respectively___Human__

FIG-65a1f4f800001380-RBBP8_CtIP_stimulates_the_endonuclease_activity_of_MRE11_following_phosphorylation_by_ATR_and_CDK1__Human__

FIG-66a3e0bb00001796-Signaling_by_Amylin_mediated_by_IAPP_ligand_activating_CALCR_RAMP1__AMYR1__receptor_complex__Human_

FIG-639bc18f00000693-Activation_of_the_CARD8_inflammasome_by_HIV_1_protease___leading_to_pyroptosis__Human_

FIG-63e5937500000215-Activation_of_the_No_Go_decay__NGD__pathway_in_response_to_ribosome_collision_by_HEL2__leading_to_ubiquitination_of_RPS7_eS7__recruitment_of_CUE2_and_mRNA_degradation__S_cerevisiae__

FIG-6606056e00002524-HIV_1_Vif_protein_hijacks_a_cullin_5_RING_E3_ubiquitin_protein_ligase_to_mediate_ubiquitination_and_degradation_of_APOBEC3G__Human__

FIG-62900b6400000076-Histone_poly_ADP_ribosylation_of_histone_H2B_at_Glu_35_by_Parp1_that_prevents_phosphorylation_at_of_histone_H2B_at_Ser_36_by_Prkaa1__Mouse_

FIG-65d7e4ac00002808-MCUB_inhibits_mitochondrial_calcium_uptake_by_the_uniplex_complex__composed_of_SMDT1_EMRE__MICU1__MICU2_and_MCU__to_prevent_calcium_overload__Human__

FIG-6205c24300000880-Regulation_of_cholesterol_biosynthesis_by_SREBP__SREBF1_and_SREBF2__and_retention_by_the_SREBP_SCAP_complex__Human_

FIG-654d809000002825-Regulation_of_endosomal_membrane_tethering_to_cleavage_furrow_during_cytokinesis_by_the_FIP3_Rab11_complex__Human_

FIG-63c0ac2b00001613-FBXO9_mediated_degradation_of_CARM1_leading_to_epithelial_cell_survival__Human_

FIG-65c57c3400000359-Dosage_compensation_in_male_Drosophila_by_the_MSL_complex__composed_of_mle__msl_1__msl_2__msl_3_and_mof___D_melanogaster__

FIG-613aae0000000061-Inhibition_of_cGAS_STING_signaling_following_dephosphorylation_of_CGAS_by_PPP6C__Human_

FIG-65f3ae5c00001022-UFL1_negatively_regulates_T_cell_activation_by_mediating_ufmylation_of_PDCD1_PD_1__Human__

FIG-645d887900001323-14_3_3_sequestering_of_ZNRF2_E3_ligase_leading_to_ATP1A1_activity_at_plasma_membrane__Human_

FIG-65a1f4f800001127-Ubiquitination_of_NBN_by_RNF8_promotes_double_strand_break_repair_via_homologous_recombination__Human__

FIG-63a86a8600000805-Positive_regulation_of_transcription_from_RNA_polymerase_II_promoter_by_glucose_3__Mouse_

FIG-65a1f4f800001740-Phosphorylation_of_MRE11_by_PLK1_and_CK2_inhibits_double_strand_break_repair_via_homologous_recombination__Human___

FIG-65692e7e00000049-GBP1_GTPase_promotes_assembly_of_the_non_canonical_inflammasome_via_association_with_lipopolysaccharide__Human__

FIG-63f809ec00000635-Activity_of_the_RQC_complex_via_ubiquitination_and_degradation_of_incompletely_synthesized_nascent_proteins__by_RQC2_and_RKR1_LTN1__following_ribosome_dissociation__S_cerevisiae__

FIG-6690711d00000331-iron_sulfur_cluster_assembly__GO_0016226__and_iron_sulfur_cluster_export_from_the_mitochondrion___GO_0140466_

FIG-6482692800000330-Regulation_of_the_canonical_mTORC1_signaling__via_deubiquitination_of_RHEB_by_ATXN3_in_response_to_starvation__Human_

FIG-66b5638000000624-Activation_of_the_integrated_stress_response_via_activation_of_EIF2AK3_PERK_in_response_to_unfolded_protein_response__Human__

FIG-YeastPathways_P4-PWY-1-superpathway_of_threonine_and_methionine_biosynthesis___imported_from__Saccharomyces_Genome_Database

FIG-66b5638000001589-Activation_of_the_integrated_stress_response_via_activation_of_EIF2AK3_PERK_in_response_to_unfolded_protein_response_promotes_expression_of_COX7A2L_SCAF1__increasing_formation_of_respiratory_chain_supercomplexes__Human__

FIG-65039e8700000055-Phosphorylation_mediated_interactions_with_TOPBP1_couples_TP53BP1_and_9_1_1_in_DNA_damage_checkpoint__Human__

FIG-6246724f00000369-Regulation_of_the_mTORC1_signaling_via_ubiquitination_and_degradation_of_CASTOR1_by_RNF167__Human__

FIG-645d887900000671-Osteocalcin__bglap__hormone_produced_by_osteoblasts_binds_Gprc6a__receptor_and_regulates_testosterone_biosynthesis_and_male_fertility__Mouse__

FIG-657ba49f00001143-tRNA_queuosine_promotes_further_glycosylation_by_GTDC1_and_B3GNTL1__and_methylation_by_TRDMT1__Human___

FIG-63c0ac2b00001853-FBXO7_mediated_degradation_of_SIRT7_leading_to_cell_death_in_response_to_hydrogen_peroxide___Human_

FIG-653b0ce600000202-BRD3_and_lncRNA_DIGIT_form_phase_separated_condensates_to_induce_endoderm_cell_differentiation__Human__

FIG-63c0ac2b00000267-IRGM_governs_the_core_autophagy_machinery_to_conduct_antimicrobial_defense__Human_

FIG-YeastPathways_TCA-EUK-PWY-TCA_cycle__aerobic_respiration___imported_from__Saccharomyces_Genome_Database

FIG-5b91dbd100002057-Antifungal_innate_immune_response_in_the_hypodermis_via_MAPK_cascade__C__elegans_

FIG-6494e2e900002525-SUCNR1_in_adipocytes_controls_energy_homeostasis_by_modulating_circadian_clock_and_LEP_expression___Human_

FIG-653b0ce600000016-Regulation_of_T_helper_17_cell_lineage_commitment_by_acetylation_and_deacetylation_of_STAT3__Human_

FIG-64e7eefa00001258-Inhibition_of_ALKBH5_RNA_demethylase_activity_by_sumoylation_in_response_to_reactive_oxygen_species__Human_

FIG-646ff70100001795-Activation_of_the_mTORC1_signaling_by_phosphorylation_of_GATOR1_subunit_DEPDC5_by_AKT1_and_PIM1__Human_

FIG-66c7d41500000163-Signaling_by_Calcitonin_CGRP_mediated_by_CALCA_CGRP1_ligand_activating_CALCR_RAMP1__AMYR1__receptor_complex__Human_

FIG-65692e7e00000243-Activation_of_the_canonical_mTORC1_signaling_by_PRMT1_in_response_to_S_adenosyl_L_methionine_influx__Human_

FIG-66b5638000001772-Signaling_by_Calcitonin_mediated_by_CALCA_CT_ligand_activating_CALCR_receptor__Human_

FIG-63f809ec00000701-tRNA_repair_and_recycling_by_ANKZF1__ELAC1_and_TRNT1_following_activity_of_the_RQC_complex_in_response_to_stalled_ribosomes__Human_

FIG-657ba49f00001888-CDK1_mediated_deubiquitination_of_CCNB1_by_USP22_leading_to_G2_M_progression__Human_

FIG-65039e8700001110-TRIM69_activation_of_STK3_by_ubiquitination_leading_to_centrosome_separation__Human_

FIG-66a3e0bb00001159-Signaling_by_Adrenomedullin_mediated_by_ADM_ligand_activating_CALCRL_RAMP2_receptor_complex__Human_

FIG-62900b6400000500-Regulation_of_ACLY_by_acetylation_by_PCAF_KAT2B_and_ubiquitination__by_UBR4___Human_

FIG-65039e8700000196-HTATSF1_and_TOPBP1_promote_RPA_RAD51_exchange_in_double_strand_break_repair_via_homologous_recombination__Human__

FIG-5b91dbd100002241-Antifungal_innate_immune_response_in_the_hypodermis_via_transforming_growth_factor_beta_receptor_signaling_pathway__C__elegans_

FIG-66187e4700001102-The_SCF_FBXO11__complex_mediates_ubiquitination_and_degradation_of_GSK3B_phosphorylated_SNAI1__Human__

FIG-66b5638000001665-Signaling_by_Calcitonin_mediated_by_CALCA_CT_ligand_activating_CALCR_RAMP2___AMYR2__receptor_complex__Human_

FIG-63c0ac2b00001143-IRGM_promotes_autophagy_dependent_degradation_of_RIPosomes__NOD1__NOD2_and_RIPK2___Human_

FIG-63c0ac2b00000331-IpaH9_8_effector_protein_from_S_flexneri_ubiquitinate_host_GBP1__leading_to_its_degradation_and_inhibition_of_innate_immunity__Human_and_S_flexneri_

FIG-66b5638000001329-ATAD3A_inhibits_the_PERK_mediated_unfolded_protein_response_in_mitochondria_by_inhibiting_EIF2AK3_PERK__Human__

FIG-639bc18f00000430-Negative_regulation_of_glycolytic_process_through_fructose_6_phosphate_2__Mouse_

FIG-62b4ffe300004953-Arginine_ADP_riboxanation_of_CASP3_by_by_C_violaceum_CopC_that_blocks_CASP3_activity__subsequent_apoptosis_and_pyroptosis__Human__

FIG-63e5937500001279-Extraction_of_mRNA_from_stalled_ribosomes_by_the_SKI_complex__leading_to_recruitment_of_the_PELO_HBS1L_complex_that_binds_to_stalled_ribosomes__followed_by_ribosome_dissociation_by_ABCE1__Human_

FIG-6482692800001739-Inhibition_of_the_canonical_mTORC1_signaling_via_phosphorylation_of_RPTOR_by_AMPK_in_response_to_glucose_starvation__Human_

FIG-66a3e0bb00001555-Signaling_by_Adrenomedullin_mediated_by_ADM_ligand_activating_CALCRL_RAMP3_receptor_complex__Human_

FIG-6690711d00001806-SIRT1_mediates_delactylation_of_YAP1_and_TEAD1__promoting_inactivation_of_Hippo_signaling__Human__

FIG-641ce4dc00000430-NOD2_localization_to_the_plasma_membrane_following_palmitoylation_by_ZDHHC5__Human_

FIG-66e382fb00002599-TBK1_activates_the_mTORC2_signaling_by_mediating_phosphorylation_of_MTOR__Human__

FIG-63f809ec00000512-Activity_of_the_RQC_complex_via_ubiquitination_and_degradation_of_incompletely_synthesized_nascent_proteins__by_NEMF_and_LTN1__following_ribosome_dissociation__Human_

FIG-65c57c3400001115-Inhibition_of_SMDT1_EMRE_and_MCU_following_cleavage_by_the_m_AAA_protease_complex__composed_of_AFG3L2_and_SPG7___Human__

FIG-65288b2200000496-Regulation_of_CGAS_activity_via_palmitoylation_and_depalmitoylation_by_ZDHHC9_and_LYPLAL1__respectively__Human__

FIG-63894f2500001894-ARRDC4_mediated_activation_of_MDA5_through_K63_ubiquitination_by_TRIM65__Human_

FIG-63e5937500000160-Activation_of_the_ribosome_quality_control__by_HEL2_in_response_to_ribosome_collisions__leading_to_ubiquitination_of_RPS20_us10_and_ribosome_dissociation_by_the_RQT_complex__composed_of_CUE3__RQT4_and_SLH1__S_cerevisiae_

FIG-63a86a8600001653-The_non_canonical_inflammasome_mediated_by_CASP4_upon_lipopolysaccharide_binding__Human_

FIG-62b4ffe300006376-HHV1_UL37_inhibition_of_host_RIG_I_signaling_via_RIG_I_deamidation__Human_Herpesvirus__

FIG-66a3e0bb00000156-Positive_regulation_of_cholesterol_biosynthesis_by_PAQR3_by_anchoring_SREBF1_SCAP_complex_to_the_Golgi____Human_

FIG-66b5638000000873-EIF2AK3_PERK_phosphorylates_NFE2L2_NRF2_in_response_to_unfolded_protein_response__preventing_the_ubiquitination_of_NFE2L2_NRF2_by_KEAP1__Human__

FIG-627d95ee00001139-Extraction_of_PARP1_trapped_to_chromatin_by_VCP_p97_following_sumoylation__by_PIAS4_and_ubiquitination_by_RNF4__Human_

FIG-62f58d8800002367-Protein_import_into_peroxisomes__of_PTS1_containing_proteins_by_the_PEX5_receptor__and_recycling_of_the_PEX5_receptor__S_cerevisiae_

FIG-646ff70100004848-Activation_of_the_canonical_mTORC1_signaling_in_response_to_insulin_via_phosphorylation_and_inhibition_of_TSC2__Human_

FIG-66187e4700000318-The_CRL5_ASB11__complex_mediates_ubiquitination_and_degradation_of_BIK_in_response_to_endoplasmic_reticulum_stress__Human__

FIG-63a86a8600001865-Irgb10_Gm12250_mediates_disruption_of_the_pathogen_membrane__liberating_ligands_that_are_detected_by_inflammasomes___Mouse_

FIG-66f5faaa00000112-TRAF6_and_HUWE1_catalyze_branched_linked_polyubiquitination_that_promote_NF_kappa_B_signaling__Human__

FIG-YeastPathways_PWY-5084-2_oxoglutarate_decarboxylation_to_succinyl_CoA___imported_from__Saccharomyces_Genome_Database

FIG-62f58d8800006929-Cleavage_of_NLRP1and_GSDMD_by_SARS_CoV_2_protease_Nsp5__leading_to_inhibition_of_GSDMD_mediated_pyroptosis_and_concomitant__initiation_of_GSDME_mediated_pyroptosis_in_lung_epithelial_cells__Human_and_SARS_CoV_2_

FIG-648d0dc100000867-Phosphorylation_of_DEPTOR_by_MAPK3_ERK1_promotes_DEPTOR_deubiquitination_by_USP7_and_enhanced_protein_stability__Human__

FIG-646ff70100004457-Phosphorylation_of_AKT1S1_PRAS40_in_response_to_insulin__relieving__AKT1S1_PRAS40_inhibitor_activity__Human_

FIG-63c0ac2b00000593-TRIM6_activation_of_antiviral_response_via_unanchored_K48_linked_polyubiquitin__Human_

FIG-66a3e0bb00000443-Positive_regulation_of_cholesterol_biosynthesis_by_PAQR3_by_anchoring_SREBF2_SCAP_complex_to_the_Golgi____Human_

FIG-6606056e00000637-UBR5_ubiquitinates_ligand_bound_PGR_when_PGR_is_not_associated_with_Nuclear_receptor_coactivators__NCOAs___Human__

FIG-65d7e4ac00001363-Mitochondrial_calcium_uptake_by_the_uniplex_complex_composed_of_SMDT1_EMRE__MICU1__MICU2_and_MCU__Human__

FIG-662af8fa00002572-Activation_of_the_non_canonical_inflammasome_mediated_by_Casp11_upon_lipopolysaccharide_binding_can_lead_to_blood_brain_barrier_breakdown__Mouse_

FIG-6606056e00000485-UBR5_ubiquitinates_ligand_bound_RARA_and_RXRA_when_RARA_and_RXRA_are_not_associated_with_Nuclear_receptor_coactivators__NCOAs___Human__

FIG-65d7e4ac00002435-MICU3_promotes_mitochondrial_calcium_uptake_by_MCU_in_the_central_nervous_system__Human__

FIG-63e5937500000106-Activation_of_the_GCN2_mediated_signaling_by_GCN1_in_response_to_ribosome_collisions_and_inhibition_of_GCN2_by_HEL2__S_cerevisiae_

FIG-66e382fb00002662-mTORC1_and_mTORC2_inhibit_insulin_receptor_signaling_by_promoting_ubiquitination_and_degradation_of_IRS1_by_the_CUL7_FBXW8__complex__Human__

FIG-6438950a00000766-Ubiquitination_of_WNK4_in_the_distal_nephron_by_KLHL3_and_its_regulation_by_phosphorylation_and_dephosphorylation__Human_

FIG-62f58d8800004946-TBC1D31_PJA2_complex_controls_primary_ciliogenesis_through_PKA_directed_OFD1_ubiquitylation__Human__

FIG-641ce4dc00000214-NOD1_signaling_in_response_to_gamma_D_glutamyl_meso_diaminopimelic_acid__iE_DAP___leading_to_NF_kappa_B_and_MAP_kinase_activation___Human_

FIG-6606056e00000317-UBR4_and_UBR5_catalyze_branched_linked_polyubiquitination_of_substrates__leading_to_proteasome_mediated_degradation_of__substrates__Human__

FIG-5fadbcf000002129-Sphingomyelin_phosphodiesterase_activity_involved_in_viral_entry__Human_Sars_Cov_2_

FIG-646ff70100003456-Inhibition_of_the_canonical_mTORC1_signaling_via_phosphorylation_of_RPTOR_by_TBK1__Human_

FIG-6494e2e900001496-MPEG1_perforin_2_forms_a_pore_for_to_deliver_antigens_for_cross_presentation__Human_

FIG-62e3212700001956-Activation_of_the_NLRP1_inflammasome_by_isoform_ZAKalpha_of_MAP3K20_in_response_to_UV_B_irradiation_and_ribotoxic_stress__Human_

FIG-63c0ac2b00000641-Lysosome_biogenesis_by_TFEB_and_regulation_of_nuclear_translocation_via_dephosphorylation_by_PPP3CB_and_regulation_by_IRGM__Human_

FIG-66e382fb00000178-Signaling_by_Vasoactive_Intestinal_Peptide_VIP_mediated_by_VIPR1_receptor__Human_

FIG-627d95ee00001242-Regulation_of_transcription_elongation_by_the_P_TEFb_complex__NELFE_and_PARP1__Human_

FIG-66187e4700000906-The_ECS_SPSB3__complex_mediates_ubiquitination_and_degradation_of_CGAS_in_the_nucleus_during_mitotic_interphase__Human__

FIG-5966411600000170-Intestinal_smooth_muscle_cell_differentiation_via_foxo1a__mir145__tgfr1b__ltbp3__zeb1a__D__rerio_

FIG-63c0ac2b00000464-Zika_virus_inhibition_of_TBK1_via_CEP63_binding_and_centrosome_disorganization__Human_Zika_virus_

FIG-6348a65d00002236-USP44_mediated_deubiquitination_of_CDC20_controlling_anaphase_initiation__Human_

FIG-6258b8f300000188-Chondroitin_sulfate_biosynthetic_process_1__chondroitin_6_sulfate_proteoglycans__Mouse_

FIG-627d95ee00002067-Regulation_of_PARP2_activity_by_PARP1_and_recruitment_of_APLF_to_DNA_damage_sites__Human_

FIG-648d0dc100000321-Phosphorylation_of_DEPTOR_in_response_to_nutrients_leads_to_its_ubiquitination_and_degradation_by_the__SCF_BTRC__complex__Human__

FIG-6348a65d00002174-USP44_mediated_FOXP3_deubiquitination_leading_to_regulatory_T_cell_differentiation__Human_

FIG-5ee8120100001898-Migrasome_signaling_involved_in_organ_morphogenesis_via_cxcl12a__cxcr4b__tspan4a__tspan7__D__rerio_

FIG-63e5937500000284-18S_rRNA_degradation_in_response_to_ribosome_collision_by_HEL2__leading_to_ubiquitination_of_RPS3_uS3_by_MAG2__RSP5_and_HEL2_and_rRNA_degradation__S_cerevisiae__

FIG-65d7e4ac00002910-AKT1_affect_mitochondrial_calcium_uptake_in_response_to_rapamycin_by_mediating_phosphorylation_of_MICU1__Human__

FIG-65c57c3400002539-The_CRL5_ASB11__complex_mediates_ubiquitination_and_degradation_of_DIRAS2__Human__

FIG-654d809000000053-Regulation_of_aggrephagy_via_acetylation_and_deacetylation_of_SQSTM1_by_KAT5_and_HDAC6__respectively___Human__

FIG-67086be200001601-Fertilization_complex_allows_sperm_egg_recognition_during_fertilization___Human_

FIG-66a3e0bb00002740-TMEFF1_restricts_herpes_simplex_virus_1__HHV_1__infection_in_the_brain_by_blocking_the_association_between_NECTIN1_and_the_viral_envelope_glycoprotein_D__Human__

FIG-65bc474400001544-Activation_of_the_GDF15_GFRAL_aversive_signaling_pathway_in_response_to_stress__Human__

FIG-662af8fa00002657-Activation_of_the_non_canonical_inflammasome_mediated_by_CASP4_upon_lipopolysaccharide_binding_can_lead_to_blood_brain_barrier_breakdown__Human_

FIG-66187e4700003150-adenylate_cyclase_activating_G_protein_coupled_receptor_signaling_pathway__GO_0007189_

FIG-66a3e0bb00002104-ITPRIPL1_is_a_ligand_of_CD3E_that_negatively_regulates_TCR_signaling_pathway___Human_

FIG-64d5781900000615-Activation_of_canonical_mTORC1_following_glycosylation_of_RPTOR_by_OGT_in_response_to_glucose_sufficiency__Human_

FIG-65a1f4f800000855-Initiation_of_double_strand_break_repair_via_homologous_recombination_by_the_MRN__complex__MRE11_RAD50_NBN___Human__

FIG-62900b6400002267-Casp7_activates_Smpd1_to_repair_Gasdermin_pores_in_intestinal_epithelial_cells___Mouse_

FIG-6606056e00000282-LGALS1_CD69_pair_involved_in_negative_regulation_of_T_helper_17_cell_lineage__Human_

FIG-622aace900000522-ADP_ribosyltransferase_activity_of_SIRT6_and_ADP_ribosylation_of_PARP1_during_DNA_repair__Human_

FIG-646ff70100000838-N_terminal_myristoylation_and_palmitoylation_of_LAMTOR1_mediates_its_recruitment_to_lysosome_membranes__Human_

FIG-62b4ffe300001832-Activation_of_CASP7_by_CASP1_in_response_to_lipopolysaccharide__leading_to_cleavage_and_degradation_of_PARP1_by_CASP7__Human_

FIG-65a1f4f800000487-Phosphorylation_of_H2AX_by_ATM_or_ATR_promotes_recruitment_of_NBN_and_MRN_complex_to_DNA_damage_sites__Human___

FIG-62f58d8800002485-Protein_import_into_peroxisomes__of_PTS1_containing_proteins_by_the_PEX5_receptor__and_recycling_of_the_PEX5_receptor__Human_

FIG-66187e4700002704-Inhibition_of_reelin_signaling_via_ubiquitination_and_degradation_of_DAB1_by_the_ECS_SOCS7__complex_in_the_cortical_plate_of_the_developing_cerebral_cortex__Human__

FIG-65288b2200000643-STING1_trafficking_from_the_endoplasmic_reticulum_and_the_ERGIC_following_phosphorylation_by_MAP3K7_TAK1_and_interaction_with_STEEP1__Human_

FIG-62f58d8800001680-Gut_Microbiota_tryptophan_metabolism__Regulation_of_intestinal_epithelial_cell_homesotasis_by_Indole_AhR__Human_E_coli_

FIG-5df932e000000330-Protease_activity_in_epithelial_morphogenesis_via_f2rl1_2__spint1a__st14a__D__rerio_

FIG-66187e4700001644-Feedback_regulation_of_growth_hormone_receptor_signaling_pathway_via_ubiquitination_and_degradation_of_GHR_by_the_ECS_SOCS2__complex__Human__

FIG-6690711d00001771-AARS1_mediates_lactylation_of_YAP1_and_TEAD1__promoting_activation_of_Hippo_signaling__Human__

FIG-65a1f4f800000428-Phosphorylation_of_MDC1_by_CK2_promotes_recruitment_of_NBN_and_MRN_complex_to_DNA_damage_sites__Human__

FIG-63c0ac2b00000547-Staphylococcal_HlgB_activation_of_NF_kappa_B_via_AMFR_and_TAB3__Human_Staphylococcus_Aureus_

FIG-645d887900000439-Contracted_muscle_secreted_FN1_activates_liver_autophagy_via_hepatic_Itga5_Itgb1_integrin_receptor_signaling___Mouse_

FIG-63a86a8600000221-positive_regulation_of_transcription_from_RNA_polymerase_II_promoter_by_glucose_1__Mouse_

FIG-62f58d8800005854-HHV1_ICP47_inhibition_of_MHC_class_I_peptide_antigen_assembly_via_TAP1_TAP2__Human_Herpesvirus__

FIG-59dc728000000555-_Wnt_FGF_Notch_signaling_inregulation_of_HSC_specification_via_dlc__dld__fgfr4__wnt16__D__rerio_

FIG-66e382fb00002738-ZDHHC1_promotes_activation_of_the_NLRP3_inflammasome_by_mediating_palmitoylation_of_NLRP3__leading_to_NLRP3_phosphorylation_by_LATS1_and_activation_of_NLRP3_by_NEK7___Human_

FIG-62b4ffe300005181-Poxvirus_OPG003_inhibition_of_host_NF_kappa_B_pathway_via_NFKB1__Human_Poxvirus__

FIG-6494e2e900001469-Mpeg1_perforin_2_forms_a_pore_for_to_deliver_antigens_for_cross_presentation__Mouse_

FIG-63d320cd00000317-Activation_of_the_AIM2_inflammasome_in_neural_cells_shapes_neurodevelopment__Mouse_

FIG-66a3e0bb00001742-Signaling_by_Calcitonin_CGRP_mediated_by_CALCB_CGRP2_ligand_activating_CALCRL_RAMP1_receptor_complex__Human_

FIG-646ff70100001877-Inhibition_of_the_canonical_mTORC1_signaling_via_ubiquitination_and_degradation_of_LAMTOR1_by_UBE3A__Human_

FIG-66a3e0bb00002776-TMEFF1_restricts_herpes_simplex_virus_1__HHV_1__in_the_brain_by_blocking_the_association_between_MYH9_and_the_viral_envelope_glycoprotein_B__Human__

FIG-6482692800000198-Regulation_of_the_canonical_mTORC1_signaling__via_ubiquitination_and_deubiquitination_of_RHEB_by_RNF152_and_USP4__respectively__Human_

FIG-6446bfcb00001000-Positive_regulation_of_epidermal_growth_factor_receptor_signaling_pathway_1__Mouse_

FIG-663d668500002178-phosphatidylinositol_phosphate_phosphatidylinositol__biosynthetic_process__GO_0006661__GO_0043647___

FIG-64e7eefa00001299-RBM33_binds_N6_methyladenosine__m6A__containing_mRNAs_and_promotes_their_demethylation_by_ALKBH5_RNA_demethylase__Human_

FIG-62b4ffe300000010-CASP7_activates_SMPD1_to_repair_Gasdermin_pores_in_intestinal_epithelial_cells__Human_

FIG-645d887900001077-Cell_type_specific__p53_independent_mitotic_G2_DNA_damage_checkpoint_signaling_mediated_by_CREB3L1_in_astrocytes___Mouse_

FIG-6348a65d00000661-Cytotoxic_T_cell_pyroptosis_mediated_by_GSDMB_isoform_1_in_response_to_infection_by_Gram_negative_bacteria_and_its_inhibition_by_S_flexneri_IpaH7_8__Human_and_S_flexneri_

FIG-641ce4dc00000050-NOD2_signaling_in_response_to_muramyl_dipeptide__MDP___leading_to_NF_kappa_B_and_MAPK_kinase_activation___Human_

FIG-65a1f4f800001246-Lactylation_of_MRE11_by_CREBBP_and_NBN_by_KAT5_in_response_to_DNA_damage_promotes_double_strand_break_repair_via_homologous_recombination__Human__

FIG-641ce4dc00000914-Activation_of_Nf_kappa_B_via_ubiquitination_and_degradation_of_the_NF_kappa_B_inhibitor__Human_

FIG-646ff70100001561-Activation_of_the_mTORC1_signaling_by_ubiquitination_and_degradation_of_GATOR1_subunit_DEPDC5_by_KLHL22__Human_

FIG-62b4ffe300000335-Perforin_maturation_leading_to_granzyme_mediated_programmed_cell_death_signaling_pathway__Human_

FIG-646ff70100005032-HCMV_UL138_substains_STAT1_activation_during_viral_latency__Human_Cytomegalovirus_

FIG-662af8fa00000002-BTRC_is_ubiquitinated_and_degraded_by_a_Cul5_RING_ubiquitin_ligase_complex__Human__

FIG-63f809ec00001358-ARKL1_negatively_negulates_Epstein_Barr_virus_reactivation_by_inhibiting_JUN_mediated_transcription___Human_Epstein_Barr_virus_

FIG-62b4ffe300004489-Regulation_of_the_JAK_STAT_pathway_by_calmodulin_in_response_to_interferon_gamma__Human_

FIG-633b013300001722-TRIM27_mediated_inhibition_of_starvation_induced_autophagy_via_ubiquitination_of_STK38L_and_ULK1__Human_

FIG-65a1f4f800001029-SKP2_mediates__Lys_63__linked_ubiquitination_of_NBN__promoting_double_strand_break_repair_via_homologous_recombination__Human__

FIG-62b4ffe300002385-Arginine_ADP_riboxanation_of_CASP4__by__by_S_flexneri_OspC3_that_blocks_CASP4_activity_and_pyroptosis__Human_

FIG-63f809ec00000560-Non_canonical_activity_of_the_RQC_complex_via_CAT_tailing_by_NEMF_that_promotes_degradation_of_incompletely_synthesized_nascent_proteins_by_the_DesCEND_pathway__Human_

FIG-65a1f4f800000553-Ubiquitination_of_NBN_by_PELI1_promotes_double_strand_break_repair_via_homologous_recombination__Human__

FIG-635b1e3e00002003-Inhibition_of_GSDMD_mediated_pyroptosis_by_M_tuberculosis_PtpB_phosphatase_that_alters_membrane_phospholipid_composition__Human_and_M_tuberculosis_

FIG-6413ac9800000654-MYD88_independent_TLR4_signaling_pathway_leading_to_interferon_production__Human_

FIG-63c0ac2b00001566-DCAF13_regulates_chromatin_reprogramming_in_the_zygote_through__SUV39H1_and_SUV39H2_degradation___Human_

FIG-63c0ac2b00000506-Degradation_of_NMNAT2_via_the_PAM__SKP1_FBXO45_MYCBP2__E3_ligase_complex__Human_

FIG-65f3ae5c00000170-Ufmylation_of_RPL26_following_translation_termination_promotes_60S_ribosomal_subunit_recycling__Human__

FIG-65a1f4f800000029-USP49_and_SIRT7_inhibition_of_AKT1_via_PHLPP1_mediated_dephosphorylation_of_AKT1__Human_

FIG-62b4ffe300000240-Perforin_maturation_leading_to_granzyme_mediated_programmed_cell_death_signaling_pathway__Mouse_

FIG-62b4ffe300004525-Regulation_of_the_JAK_STAT_pathway_by_calmodulin_in_response_to_interferon_beta__Human_

FIG-66187e4700002599-SECTM1_CD7_interaction_leading_to_cytokine_production_upon_T_cell_activation__Human_

FIG-66e382fb00000254-Signaling_by_Vasoactive_Intestinal_Peptide_VIP_mediated_by_VIPR2_receptor__Human_

FIG-6606056e00000576-UBR5_ubiquitinates_ligand_bound_VDR_when_VDR_is_not_associated_with_Nuclear_receptor_coactivators__NCOAs___Human__

FIG-66187e4700001030-The_ECS_SPSB3__complex_mediates_ubiquitination_and_degradation_of_GSK3B_phosphorylated_SNAI1__Human__

FIG-623d156d00000817-Role_of_TONSL_and_MMS22L__TONSL_MMS22L_complex__in_promoting_homologous_recombination_mediated_repair_of_DSBs__Human_

FIG-6246724f00000283-Regulation_of_the_mTORC1_signaling_via_ubiquitination_and_deubiquitnation_of_SESN2_by_RNF167_and_STAMBPL1__Human_

FIG-62900b6400001385-Lysosome_biogenesis_by_TFEB_and_regulation_of_cytoplasmic_retention_via_phosphorylation_by_MTOR_or_alkylation__Human_

FIG-646ff70100003516-Activation_of_mTORC1_signaling_following_phosphorylation_of_MTOR_by_TBK1__Human_

FIG-666b894f00001488-HTR2C_mediated_serotonin_signaling_via_G_alpha_q_11__phospholipase_c_activating__IP3__DAG___Human__

FIG-66e382fb00001531-GSK3B_inhibits_the_mTORC2_pathway_by_mediating_phosphorylation_of_RICTOR_in_response_to_endoplasmic_reticulum_stress__Human__

FIG-641ce4dc00000586-UBL7_TRIM21_mediated_ubiquitination_of_MAVS_leading_to_type_I_interferon_production__Human_

FIG-65bc474400000955-Negative_regulation_of_Hippo_signaling_by_STRIPAK_complex_via_STRN4_MAP4K4_Human__

FIG-65c57c3400000173-The_MSL_complex__composed_of_MSL1__MSL2__MSL3_and_KAT8__mediates_acetylation_of_histone_H4_at_Lys_16__H4K16ac___Human__

FIG-662af8fa00002457-O_GlcNAcylation_of_GSDMD_by_OGT_inhibits_the_non_canonical_inflammasome_assembly__Human_

FIG-66187e4700002129-Feedback_regulation_of_erythropoietin_mediated_signaling_via_ubiquitination_and_degradation_of_EPOR_by_the_ECS_SOCS2__complex__Human__